PMID- 22607459
OWN - NLM
STAT- MEDLINE
DCOM- 20121221
LR  - 20240318
IS  - 1471-2466 (Electronic)
IS  - 1471-2466 (Linking)
VI  - 12
DP  - 2012 May 20
TI  - Assessing health status in COPD. A head-to-head comparison between the COPD 
      assessment test (CAT) and the clinical COPD questionnaire (CCQ).
PG  - 20
LID - 10.1186/1471-2466-12-20 [doi]
AB  - BACKGROUND: Health status provides valuable information, complementary to 
      spirometry and improvement of health status has become an important treatment 
      goal in COPD management. We compared the usefulness and validity of the COPD 
      Assessment Test (CAT) and the Clinical COPD Questionnaire (CCQ), two simple 
      questionnaires, in comparison with the St. George Respiratory Questionnaire 
      (SGRQ). METHODS: We administered the CAT, CCQ and SGRQ in patients with COPD 
      stage I-IV during three visits. Spirometry, 6 MWT, MRC scale, BODE index, and 
      patients perspectives on questionnaires were recorded in all visits. Standard 
      Error of Measurement (SEM) was used to calculate the Minimal Clinical Important 
      Difference (MCID) of all questionnaires. RESULTS: We enrolled 90 COPD patients. 
      Cronbach's alpha for both CAT and CCQ was high (0.86 and 0.89, respectively). 
      Patients with severe COPD reported worse health status compared to milder 
      subgroups. CAT and CCQ correlated significantly (rho =0.64, p < 0.01) and both 
      with the SGRQ (rho = 0.65; CAT and rho = 0.77; CCQ, p < 0.01). Both 
      questionnaires exhibited a weak correlation with lung function (rho = -0.35;CAT 
      and rho = -0.41; CCQ, p < 0.01). Their reproducibility was high; CAT: ICC = 0.94 
      (CI 0.92-0.96), total CCQ ICC = 0.95 (0.92-0.96) and SGRQ = 0.97 (CI 0.95-0.98). 
      The MCID calculated using the SEM method showed results similar to previous 
      studies of 3.76 for the CAT, 0.41 for the CCQ and 4.84 for SGRQ. Patients 
      suggested both CAT and CCQ as easier tools than SGRQ in terms of complexity and 
      time considerations. More than half of patients preferred CCQ instead of CAT. 
      CONCLUSIONS: The CAT and CCQ have similar psychometric properties with a slight 
      advantage for CCQ based mainly on patients' preference and are both valid and 
      reliable questionnaires to assess health status in COPD patients.
FAU - Tsiligianni, Ioanna G
AU  - Tsiligianni IG
AD  - Department of Thoracic Medicine, Medical School, University of Crete, Heraklion, 
      Crete, PO 71003, Greece. i.tsiligianni@med.umcg.nl
FAU - van der Molen, Thys
AU  - van der Molen T
FAU - Moraitaki, Despoina
AU  - Moraitaki D
FAU - Lopez, Ilaine
AU  - Lopez I
FAU - Kocks, Janwillem W H
AU  - Kocks JW
FAU - Karagiannis, Konstantinos
AU  - Karagiannis K
FAU - Siafakas, Nikolaos
AU  - Siafakas N
FAU - Tzanakis, Nikolaos
AU  - Tzanakis N
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
DEP - 20120520
PL  - England
TA  - BMC Pulm Med
JT  - BMC pulmonary medicine
JID - 100968563
SB  - IM
MH  - Aged
MH  - Female
MH  - *Health Status Indicators
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Preference/statistics & numerical data
MH  - Psychometrics
MH  - Pulmonary Disease, Chronic Obstructive/*diagnosis/physiopathology
MH  - Reproducibility of Results
MH  - Severity of Illness Index
MH  - Spirometry
MH  - Surveys and Questionnaires
PMC - PMC3431277
EDAT- 2012/05/23 06:00
MHDA- 2012/12/22 06:00
PMCR- 2012/05/20
CRDT- 2012/05/22 06:00
PHST- 2012/01/12 00:00 [received]
PHST- 2012/05/03 00:00 [accepted]
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/12/22 06:00 [medline]
PHST- 2012/05/20 00:00 [pmc-release]
AID - 1471-2466-12-20 [pii]
AID - 10.1186/1471-2466-12-20 [doi]
PST - epublish
SO  - BMC Pulm Med. 2012 May 20;12:20. doi: 10.1186/1471-2466-12-20.