PMID- 22609259
OWN - NLM
STAT- MEDLINE
DCOM- 20121128
LR  - 20151119
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 413
IP  - 19-20
DP  - 2012 Oct 9
TI  - The levels of circulating and urinary monocyte chemoattractant protein-1 are 
      associated with chronic renal injury in obese men.
PG  - 1647-51
LID - 10.1016/j.cca.2012.05.008 [doi]
AB  - BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) is a vital inflammatory 
      marker of obesity. Whether obesity by itself increases the risk of chronic kidney 
      injury and accelerates its progression is unknown. More importantly, it is 
      unknown whether obesity could induce kidney injury by MCP-1. METHODS: We enrolled 
      40 obese men and 26 healthy volunteers who served as controls. The degree of 
      insulin resistance was evaluated by the homeostasis model assessment (HOMA-IR) 
      method, and kidney function was determined based on the estimated glomerular 
      filtration rate (eGFR), albuminuria, the concentration of serum cystatin C 
      (S-CysC), and the urinary cystatin C to creatinine ratio (UCCR). RESULTS: The 
      obese subjects had significantly higher S-CysC concentration (1114+/-288 vs.962+/-169 
      mg/L, p=0.021) and a higher UCCR (3.5+/-1.6 vs. 2.5+/-0.8 mug/g, p=0.002) than those 
      of controls. The concentration of circulating MCP-1 and the urinary MCP-1 to 
      creatinine ratio (UMCR) were higher in the obese group and were correlated with 
      fat mass and HOMA-IR. Using stepwise multiple linear regression analysis, 
      circulating MCP-1 concentration was found to be independently associated with the 
      amount of S-CysC. In addition, the UMCR was independently associated with the 
      UCCR. CONCLUSION: The concentrations of circulating and urinary monocyte 
      chemoattractant protein-1 are associated with chronic renal injury in obese men.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Fu, Chia-Po
AU  - Fu CP
AD  - Division of Endocrinology and Metabolism, Department of Medicine, Taichung 
      Veterans General Hospital, Taichung, Taiwan.
FAU - Lee, I-Te
AU  - Lee IT
FAU - Sheu, Wayne H-H
AU  - Sheu WH
FAU - Lee, Wen-Jane
AU  - Lee WJ
FAU - Liang, Kae-Woei
AU  - Liang KW
FAU - Lee, Wen-Lieng
AU  - Lee WL
FAU - Lin, Shih-Yi
AU  - Lin SY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120515
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cystatin C)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adipose Tissue/metabolism/pathology
MH  - Adult
MH  - Albuminuria/*blood/complications/*urine
MH  - Biomarkers/blood/urine
MH  - Body Mass Index
MH  - *Chemokine CCL2/blood/urine
MH  - Creatinine/blood/urine
MH  - Cystatin C/blood/urine
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Insulin Resistance
MH  - Kidney/metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Monocytes/metabolism/pathology
MH  - Obesity/*blood/complications/*urine
MH  - Renal Insufficiency, Chronic/*blood/complications/*urine
EDAT- 2012/05/23 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/02/24 00:00 [received]
PHST- 2012/04/23 00:00 [revised]
PHST- 2012/05/09 00:00 [accepted]
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0009-8981(12)00234-3 [pii]
AID - 10.1016/j.cca.2012.05.008 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2012 Oct 9;413(19-20):1647-51. doi: 10.1016/j.cca.2012.05.008. 
      Epub 2012 May 15.