PMID- 22609366
OWN - NLM
STAT- MEDLINE
DCOM- 20130227
LR  - 20120924
IS  - 1873-2402 (Electronic)
IS  - 0006-3223 (Linking)
VI  - 72
IP  - 8
DP  - 2012 Oct 15
TI  - Neurotrophic tyrosine kinase polymorphism impacts white matter connections in 
      patients with major depressive disorder.
PG  - 663-70
LID - S0006-3223(12)00367-8 [pii]
LID - 10.1016/j.biopsych.2012.04.015 [doi]
AB  - BACKGROUND: Polymorphisms in the brain-derived neurotrophic factor (BDNF) gene 
      and its receptor neurotrophic tyrosine kinase receptor type 2 (NTRK2) have been 
      implicated in mood disorders. The aim of this study was to examine whether the 
      NTRK2 and BDNF polymorphisms impact brain white matter connections in major 
      depressive disorder and whether they may also have an interactive effect with 
      environmental stress in the form of early life adversity. METHODS: The study 
      group comprised 45 depressed patients and 45 age- and gender-matched control 
      subjects. High angular resolution diffusion images were obtained and analyzed 
      using tract-based spatial statistics. Analysis of a single nucleotide 
      polymorphism in the BDNF (rs6265/Valine66Methionine) and NTRK2 (rs11140714) genes 
      was performed. RESULTS: An interactive effect was found between NTRK2 and 
      depression diagnosis maximally affecting the cingulum. Depressed patients 
      homozygous for the A allele of NTRK2 showed significantly reduced fractional 
      anisotropy compared with depressed patients with at least one copy of the G 
      allele or control subjects with either the A/A or G carrier genotypes in the left 
      and right corona radiata, left uncinate fasciculus, left inferior 
      fronto-occipital fasciculus, left cerebral peduncle, posterior thalamic 
      radiation, and middle cerebral peduncle. Significantly smaller gray matter volume 
      was seen in frontal lobe regions in patients homozygous for the A allele. 
      CONCLUSIONS: Polymorphisms in NTRK2 gene increase risk of architectural changes 
      in several brain regions involved in emotional regulation.
CI  - Copyright (c) 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All 
      rights reserved.
FAU - Murphy, Melissa L
AU  - Murphy ML
AD  - Integrated Neuroimaging Group, Department of Psychiatry and Institute of 
      Neuroscience, School of Medicine, Trinity College Dublin, University of Dublin, 
      College Green, Dublin, Ireland.
FAU - Carballedo, Angela
AU  - Carballedo A
FAU - Fagan, Andrew J
AU  - Fagan AJ
FAU - Morris, Derek
AU  - Morris D
FAU - Fahey, Ciara
AU  - Fahey C
FAU - Meaney, James
AU  - Meaney J
FAU - Frodl, Thomas
AU  - Frodl T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120519
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Anisotropy
MH  - Brain/*pathology
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Depressive Disorder, Major/*genetics/*pathology
MH  - Diffusion Tensor Imaging
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers, Myelinated/*pathology
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Psychiatric Status Rating Scales
MH  - Receptor, trkB/*genetics
MH  - Young Adult
EDAT- 2012/05/23 06:00
MHDA- 2013/02/28 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/02/21 00:00 [received]
PHST- 2012/04/02 00:00 [revised]
PHST- 2012/04/12 00:00 [accepted]
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2013/02/28 06:00 [medline]
AID - S0006-3223(12)00367-8 [pii]
AID - 10.1016/j.biopsych.2012.04.015 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2012 Oct 15;72(8):663-70. doi: 10.1016/j.biopsych.2012.04.015. 
      Epub 2012 May 19.