PMID- 22610036
OWN - NLM
STAT- MEDLINE
DCOM- 20120815
LR  - 20161125
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 168
DP  - 2012 Sep
TI  - Accumulation of dioxins and induction of cytochrome P450 1A4/1A5 enzyme 
      activities in common cormorants from Lake Biwa, Japan: temporal trends and 
      validation of national regulation on dioxins emission.
PG  - 131-7
LID - 10.1016/j.envpol.2012.04.014 [doi]
AB  - To validate the outcome of the national regulation on dioxins emission 
      implemented in 1999, this study investigated temporal trends of chlorinated 
      dioxins and related compounds (DRCs) in liver of common cormorants (Phalacrocorax 
      carbo) collected from Lake Biwa, Japan between 2001 and 2008, as a part of the 
      "Survey on the State of Dioxins Accumulation in Wildlife" conducted by the 
      Ministry of the Environment, Japan. We also measured a biomarker of DRCs 
      exposure, the cytochrome P450 1A (CYP1A)-dependent O-dealkylation activity of 
      alkoxyresorufins (AROD), including methoxy-, ethoxy-, pentoxy- and 
      benzyloxy-resorufins in the samples over 2001-2007. Neither TEQ nor AROD activity 
      showed any clear declining trend over the time period, although the emission of 
      DRCs during the corresponding period was estimated to be apparently decreasing. 
      Our data indicate that the concentration of recalcitrant DRCs in the cormorant 
      during 2001-2008 was scarcely affected by the national regulation on dioxins 
      emission.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Kubota, Akira
AU  - Kubota A
AD  - Center for Marine Environmental Studies, Ehime University, 2-5 Bunkyo-cho, 
      Matsuyama 790-8577, Japan.
FAU - Watanabe, Michio X
AU  - Watanabe MX
FAU - Kim, Eun-Young
AU  - Kim EY
FAU - Yoneda, Kumiko
AU  - Yoneda K
FAU - Tanabe, Shinsuke
AU  - Tanabe S
FAU - Iwata, Hisato
AU  - Iwata H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120518
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Benzofurans)
RN  - 0 (Dibenzofurans, Polychlorinated)
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - EC 1.- (methoxyresorufin-O-demethylase)
RN  - EC 1.14.14.1 (Aryl Hydrocarbon Hydroxylases)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP2B1)
SB  - IM
MH  - Animals
MH  - Aryl Hydrocarbon Hydroxylases/*metabolism
MH  - Benzofurans/metabolism/toxicity
MH  - Birds/*metabolism
MH  - Cytochrome P-450 CYP1A1/metabolism
MH  - Cytochrome P-450 CYP2B1/metabolism
MH  - Cytochrome P-450 Enzyme System/metabolism
MH  - Dibenzofurans, Polychlorinated
MH  - Dioxins/*metabolism/toxicity
MH  - Environmental Monitoring
MH  - Environmental Policy
MH  - Environmental Pollutants/*metabolism/toxicity
MH  - Environmental Pollution/prevention & control/statistics & numerical data
MH  - Enzyme Induction
MH  - Female
MH  - Japan
MH  - Lakes
MH  - Liver/enzymology
MH  - Male
MH  - Polychlorinated Biphenyls/metabolism/toxicity
MH  - Polychlorinated Dibenzodioxins/analogs & derivatives/metabolism/toxicity
EDAT- 2012/05/23 06:00
MHDA- 2012/08/16 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/02/29 00:00 [received]
PHST- 2012/04/11 00:00 [revised]
PHST- 2012/04/12 00:00 [accepted]
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/08/16 06:00 [medline]
AID - S0269-7491(12)00196-0 [pii]
AID - 10.1016/j.envpol.2012.04.014 [doi]
PST - ppublish
SO  - Environ Pollut. 2012 Sep;168:131-7. doi: 10.1016/j.envpol.2012.04.014. Epub 2012 
      May 18.