PMID- 22610875
OWN - NLM
STAT- MEDLINE
DCOM- 20140617
LR  - 20151119
IS  - 1522-7278 (Electronic)
IS  - 1520-4081 (Linking)
VI  - 29
IP  - 5
DP  - 2014 May
TI  - Responses of biomarkers of a standardized (Cyprinus carpio) and a native 
      (Pimelodella laticeps) fish species after in situ exposure in a periurban zone of 
      Lujan river (Argentina).
PG  - 545-57
LID - 10.1002/tox.21780 [doi]
AB  - The Lujan River basin, which is located in the northwest area of the province of 
      Buenos Aires, Argentina, receives different anthropogenic inputs before reaching 
      the Rio de la Plata estuary. The aim of this study was to assess the adverse 
      impact of the river in the middle part of the basin. To this end, an in situ cage 
      assay was conducted in two sites of the river (S1 and S2) near Lujan city, and 
      the responses of hepatic biomarkers of both a standardized (Cyprinus carpio) and 
      a native (Pimelodella laticeps) species were evaluated. The biomarkers studied 
      were the condition factor and liver somatic indices (LSI), the enzymatic 
      activities of catalase (CAT), superoxide dismutase (SOD), and 
      glutathione-S-transferase (GST), lipid peroxidation levels (thiobarbituric acid 
      reactive substances, TBARS) and the induction of hepatic cytochrome P450 1A 
      (CYP1A) and vitellogenin (Vtg) proteins. After 14 days, LSI and GST activity 
      increased, and TBARS levels decreased in both species exposed at S1 and S2. In 
      addition, exposure at both sites promoted an increase in SOD activity and CYP1A 
      induction in C. carpio, while Vtg expression was observed only at S1. A shorter 
      exposure period (7 days) caused an initial response only at S2 mediated only by 
      CAT in P. laticeps. Finally, our results demonstrate that a 14-day period of in 
      situ exposure in Lujan River could lead to antioxidant and biotransformation 
      processes in C. carpio and to phase II biotransformation responses in P. 
      laticeps.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Scarcia, Paola
AU  - Scarcia P
AD  - Programa de Ecofisiologia Aplicada (PRODEA-INEDES), Departamento de Ciencias 
      Basicas, Universidad Nacional de Lujan, Casilla de Correo 221, B6700ZB, Lujan, 
      Argentina; Consejo Nacional de Investigaciones Cientificas y Tecnologicas 
      (CONICET), Buenos Aires, Argentina, >
FAU - Calamante, Gabriela
AU  - Calamante G
FAU - de la Torre, Fernando
AU  - de la Torre F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120519
PL  - United States
TA  - Environ Toxicol
JT  - Environmental toxicology
JID - 100885357
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 0 (Vitellogenins)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 2.5.1.18 (Glutathione Transferase)
SB  - IM
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Argentina
MH  - Biomarkers/*metabolism
MH  - Biotransformation
MH  - *Carps
MH  - Catalase/metabolism
MH  - *Catfishes
MH  - Cytochrome P-450 CYP1A1/metabolism
MH  - Glutathione Transferase/metabolism
MH  - Lipid Peroxidation
MH  - Liver/*enzymology
MH  - Oxidative Stress
MH  - Rivers/*chemistry
MH  - Superoxide Dismutase/metabolism
MH  - Thiobarbituric Acid Reactive Substances/metabolism
MH  - Vitellogenins/metabolism
MH  - Water Pollution/*adverse effects
OTO - NOTNLM
OT  - Cyprinus carpio
OT  - biochemical and molecular biomarkers
OT  - field caging assay
OT  - native fish species
OT  - periurban Lujan River
EDAT- 2012/05/23 06:00
MHDA- 2014/06/18 06:00
CRDT- 2012/05/22 06:00
PHST- 2012/01/25 00:00 [received]
PHST- 2012/03/20 00:00 [revised]
PHST- 2012/03/21 00:00 [accepted]
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2014/06/18 06:00 [medline]
AID - 10.1002/tox.21780 [doi]
PST - ppublish
SO  - Environ Toxicol. 2014 May;29(5):545-57. doi: 10.1002/tox.21780. Epub 2012 May 19.