PMID- 22610920
OWN - NLM
STAT- MEDLINE
DCOM- 20121011
LR  - 20220310
IS  - 1552-485X (Electronic)
IS  - 1552-4841 (Print)
IS  - 1552-4841 (Linking)
VI  - 159B
IP  - 5
DP  - 2012 Jul
TI  - The brain-derived neurotrophic-factor (BDNF) val66met polymorphism is associated 
      with geriatric depression: a meta-analysis.
PG  - 560-6
LID - 10.1002/ajmg.b.32062 [doi]
AB  - Depression has been associated with reduced expression of brain-derived 
      neurotrophic factor (BDNF) in the hippocampus. Genetic association studies of the 
      BDNF Val66Met polymorphism (rs6265) in geriatric depression have produced 
      inconsistent results. A meta-analysis of studies was conducted to compare the 
      frequency of the BDNF Val66Met variant between cases with geriatric depression 
      and age-matched controls. A total of five studies involving 523 cases with 
      geriatric depression and 1,220 psychiatrically healthy controls was included. Met 
      allele carriers had an increased risk for geriatric depression when compared to 
      Val/Val homozygotes (P = 0.004, OR = 1.48, 95% CI = 1.13-1.93). Our findings 
      suggest the BDNF Met allele may confer increased risk for depression as 
      individual age.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Pei, Yu
AU  - Pei Y
AD  - Beijing Anding Hospital, Capital Medical University, Beijing, China.
FAU - Smith, Alicia K
AU  - Smith AK
FAU - Wang, Yongjun
AU  - Wang Y
FAU - Pan, Yanli
AU  - Pan Y
FAU - Yang, Jian
AU  - Yang J
FAU - Chen, Qi
AU  - Chen Q
FAU - Pan, Weigang
AU  - Pan W
FAU - Bao, Feng
AU  - Bao F
FAU - Zhao, Lisha
AU  - Zhao L
FAU - Tie, Changle
AU  - Tie C
FAU - Wang, Yizheng
AU  - Wang Y
FAU - Wang, Jian
AU  - Wang J
FAU - Zhen, Wenfeng
AU  - Zhen W
FAU - Zhou, Jinxia
AU  - Zhou J
FAU - Ma, Xin
AU  - Ma X
LA  - eng
GR  - K01 MH085806/MH/NIMH NIH HHS/United States
GR  - MH085806/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120518
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Amino Acid Substitution/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Depression/*genetics
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Publication Bias
PMC - PMC3549636
MID - NIHMS430811
COIS- The authors declared that they have no conflicts of interest.
EDAT- 2012/05/23 06:00
MHDA- 2012/10/12 06:00
PMCR- 2013/01/21
CRDT- 2012/05/22 06:00
PHST- 2011/12/30 00:00 [received]
PHST- 2012/04/25 00:00 [accepted]
PHST- 2012/05/22 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
PHST- 2013/01/21 00:00 [pmc-release]
AID - 10.1002/ajmg.b.32062 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2012 Jul;159B(5):560-6. doi: 
      10.1002/ajmg.b.32062. Epub 2012 May 18.