PMID- 22612248
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20130108
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Linking)
VI  - 53
IP  - 1
DP  - 2013 Jan
TI  - Analysis of stored and transplanted cord blood units from KoreaCORD: reappraisal 
      of banking guidelines and selection strategy.
PG  - 123-7
LID - 10.1111/j.1537-2995.2012.03712.x [doi]
AB  - BACKGROUND: We analyzed the characteristics of stored and transplanted cord blood 
      (CB) units from the Korean network for public CB donation (KoreaCORD) to reassess 
      the banking guidelines and optimize CB selection based on cell dose and human 
      leukocyte antigen (HLA) mismatching. STUDY DESIGN AND METHODS: We retrospectively 
      reviewed data, with regard to total nucleated cell (TNC) count and HLA match in 
      the KoreaCORD registry from August 2001 to December 2010. RESULTS: A total of 
      21,914 CB units have been registered, of which 904 units (4.1%) contained less 
      than 5 x 10(8) TNCs, which did not meet the present storage criteria for public 
      CB banking in Korea. Although the proportion of stored CBs providing TNC of 
      5 x 10(8) to 7.9 x 10(8) was 45.7%, only 22.0% of all transplanted CBs were 
      derived from these stored CBs. In the single CB transplantation setting, 79% 
      (85/108) of CB units provided 4 x 10(7) TNCs/kg or more in the transplanted 
      one-mismatch (1-MM) CB units and 51% (19/37) of CBs provided 6 x 10(7) TNCs/kg or 
      more in the transplanted 2-MM CB units. CONCLUSIONS: The minimal requirement of 
      TNCs for banking of CB units for public banking should be evaluated and increased 
      to support the selection of CB units with higher cell doses, especially for use 
      in the 1- and 2-MM transplant settings.
CI  - (c) 2012 American Association of Blood Banks.
FAU - Lee, Young-Ho
AU  - Lee YH
AD  - Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School 
      of Medicine, 50 Irwon-dong, Gangnamgu, Seoul 135-710, Korea. hhkoo@skku.edu
FAU - Kwon, Young-Hee
AU  - Kwon YH
FAU - Hwang, Kyoujung
AU  - Hwang K
FAU - Jun, Hyunju
AU  - Jun H
FAU - Lee, Mi-Ae
AU  - Lee MA
FAU - Jang, Hyung-In
AU  - Jang HI
FAU - Nah, Jung-Hwa
AU  - Nah JH
FAU - Koo, Hong-Hoe
AU  - Koo HH
FAU - Hwang, Tai-Ju
AU  - Hwang TJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120521
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Blood Banks
MH  - *Cord Blood Stem Cell Transplantation
MH  - HLA Antigens/immunology
MH  - Humans
MH  - Korea
MH  - Retrospective Studies
EDAT- 2012/05/23 06:00
MHDA- 2013/03/15 06:00
CRDT- 2012/05/23 06:00
PHST- 2012/05/23 06:00 [entrez]
PHST- 2012/05/23 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
AID - 10.1111/j.1537-2995.2012.03712.x [doi]
PST - ppublish
SO  - Transfusion. 2013 Jan;53(1):123-7. doi: 10.1111/j.1537-2995.2012.03712.x. Epub 
      2012 May 21.