PMID- 22613489 OWN - NLM STAT- MEDLINE DCOM- 20121022 LR - 20120611 IS - 1532-2653 (Electronic) IS - 0967-5868 (Linking) VI - 19 IP - 7 DP - 2012 Jul TI - Roles of brain-derived neurotrophic factor/tropomyosin-related kinase B (BDNF/TrkB) signalling in Alzheimer's disease. PG - 946-9 LID - 10.1016/j.jocn.2011.12.022 [doi] AB - Alzheimer's disease (AD) is one of the most common causes of dementia in the elderly. It is characterized by extracellular deposition of the neurotoxic peptide, amyloid-beta (Abeta) peptide fibrils, and is accompanied by extensive loss of neurons in the brains of affected individuals. However, the pathogenesis of AD is not fully understood. The aim of this review is to discuss the possible role of brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) signalling in the development of AD, focusing on BDNF/TrkB signalling in the production of Abeta, tau hyperphosphorylation and cognition decline, and exploring new possibilities for AD intervention. CI - Copyright (c) 2012 Elsevier Ltd. All rights reserved. FAU - Zhang, Fang AU - Zhang F AD - Institute of Molecular and Clinical Medicine, Kunming Medical University, 1168, West Chunrong Road, Yuhua Street, Chenggong New Town, Kunming 650500, China. wsnd222111@yahoo.cn FAU - Kang, Zhilong AU - Kang Z FAU - Li, Wen AU - Li W FAU - Xiao, Zhicheng AU - Xiao Z FAU - Zhou, Xinfu AU - Zhou X LA - eng PT - Journal Article PT - Review DEP - 20120520 PL - Scotland TA - J Clin Neurosci JT - Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia JID - 9433352 RN - 0 (Brain-Derived Neurotrophic Factor) RN - EC 2.7.10.1 (Receptor, trkB) SB - IM MH - Alzheimer Disease/complications/genetics/*metabolism MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Humans MH - Receptor, trkB/*metabolism MH - Signal Transduction/*physiology EDAT- 2012/05/23 06:00 MHDA- 2012/10/23 06:00 CRDT- 2012/05/23 06:00 PHST- 2011/11/29 00:00 [received] PHST- 2011/12/15 00:00 [revised] PHST- 2011/12/17 00:00 [accepted] PHST- 2012/05/23 06:00 [entrez] PHST- 2012/05/23 06:00 [pubmed] PHST- 2012/10/23 06:00 [medline] AID - S0967-5868(12)00135-X [pii] AID - 10.1016/j.jocn.2011.12.022 [doi] PST - ppublish SO - J Clin Neurosci. 2012 Jul;19(7):946-9. doi: 10.1016/j.jocn.2011.12.022. Epub 2012 May 20.