PMID- 22615607
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20240315
IS  - 1560-8115 (Print)
IS  - 2008-2231 (Electronic)
IS  - 1560-8115 (Linking)
VI  - 18
IP  - 2
DP  - 2010
TI  - An investigation of the neuroprotective effects of Curcumin in a model of 
      Homocysteine - induced oxidative stress in the rat's brain.
PG  - 128-36
AB  - BACKGROUND AND THE PURPOSE OF THE STUDY: Aging is the major risk factor for 
      neurodegenerative diseases and oxidative stress is involved in the 
      pathophysiology of them. Oxidative stress can induce neuronal damages and 
      modulate intracellular signaling, ultimately leading to neuronal death by 
      apoptosis or necrosis. In this study, the possible antioxidant and 
      neuroprotective properties of the natural polyphenolic antioxidant compound, 
      curcumin against homocysteine (Hcy) neurotoxicity was investigated. METHODS: 
      Curcumin (5, 15, 45 mg/kg) was injected intraperitonealy (i.p.) once daily for a 
      period of 10 days beginning 5 days prior to Hcy (0.2 micromol/microl) 
      intracerebroventricular (i.c.v) injection in rats. Biochemical and behavioral 
      studies, including passive avoidance learning and locomotor activity tests were 
      studied 24 hrs after the last curcumin or its vehicle injection. The cell density 
      of hippocampus layers and apoptosis in rats' hippocampi by immunohistochical 
      methods were also studied. RESULTS AND MAJOR CONCLUSION: Results indicated that 
      Hcy could induce lipid peroxidation and increase Malondialdehyde (MDA) and Super 
      Oxide Anion (SOA) levels in rat's brain. Additionally, Hcy impaired memory 
      retention in passive avoidance learning test. However, curcumin decreased MDA and 
      SOA levels significantly and improved learning and memory in rats. On the other 
      hand Hcy could induce cell death and apoptosis in rats' hippocampi which was 
      inhibited by curcumin. These results suggest that Hcy may induce lipid 
      peroxidation in rat's brain. and polyphenol treatment (curcumin) improves 
      learning and memory deficits by protecting the nervous system against Oxidative 
      stress.
FAU - Ataie, A
AU  - Ataie A
AD  - Neuroscience Research Center, M.C.
FAU - Sabetkasaei, M
AU  - Sabetkasaei M
FAU - Haghparast, A
AU  - Haghparast A
FAU - Hajizadeh Moghaddam, A
AU  - Hajizadeh Moghaddam A
FAU - Ataie, R
AU  - Ataie R
FAU - Nasiraei Moghaddam, Sh
AU  - Nasiraei Moghaddam Sh
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Daru
JT  - Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
JID - 101125969
PMC - PMC3304371
OTO - NOTNLM
OT  - Curcumin
OT  - Homocysteine
OT  - Lipid peroxidation
OT  - Oxidative stress
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
PMCR- 2010/01/01
CRDT- 2012/05/23 06:00
PHST- 2009/08/26 00:00 [received]
PHST- 2009/12/14 00:00 [revised]
PHST- 2009/12/20 00:00 [accepted]
PHST- 2012/05/23 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PHST- 2010/01/01 00:00 [pmc-release]
AID - DARU-18-128 [pii]
PST - ppublish
SO  - Daru. 2010;18(2):128-36.