PMID- 22616617
OWN - NLM
STAT- MEDLINE
DCOM- 20130201
LR  - 20120914
IS  - 1600-0447 (Electronic)
IS  - 0001-690X (Linking)
VI  - 126
IP  - 4
DP  - 2012 Oct
TI  - Symptomatic and functional remission in patients with first-episode psychosis.
PG  - 282-9
LID - 10.1111/j.1600-0447.2012.01883.x [doi]
AB  - OBJECTIVE: For patients suffering from psychotic disorders and their caregivers, 
      'recovery' remains important. Our study aims to examine the rates of both 
      symptomatic and functional remission in first-episode psychosis (FEP) patients at 
      2 years and identify sociodemographic and clinical factors associated with 
      recovery. METHOD: In this naturalistic study, all consecutive FEP patients 
      presenting to an early psychosis intervention programme were recruited. 
      Symptomatic remission was defined by the Schizophrenia Working Group's criteria; 
      functional remission was defined as a Global Assessment of Functioning (GAF) 
      disability score of >/=61 with engagement in age-appropriate vocation. Simple and 
      multiple logistic regressions using stepwise method were used. RESULTS: Out of 
      1175 patients, 636 (54.1%) met criteria for symptomatic remission, 686 (58.4%) 
      for functional remission, while 345 (29.4%) met for both. Multiple logistic 
      regression revealed female gender (OR 1.47; 95%CI, 1.12-1.93), those married (OR 
      1.49; 95%CI, 1.02-2.18), younger age (OR 0.98; 95%CI, 0.95-0.99), tertiary 
      education (OR 1.56; 95%CI, 1.02-2.38), shorter DUP (OR 0.99; 95%CI, 0.98-0.99), 
      lower baseline PANSS negative scores (OR 0.97; 95%CI, 0.95-0.99), and early 
      response at month 3 (OR 1.78; 95%CI, 1.31-2.42), as significant predictors of 
      recovery at year 2. CONCLUSION: Our results indicate that strategies to reduce 
      DUP and achieve early response could improve remission rates in FEP patients.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Verma, S
AU  - Verma S
AD  - Department of Early Psychosis Intervention, Institute of Mental Health, 
      Singapore, Singapore. swapna_verma@imh.com.sg
FAU - Subramaniam, M
AU  - Subramaniam M
FAU - Abdin, E
AU  - Abdin E
FAU - Poon, L Y
AU  - Poon LY
FAU - Chong, S A
AU  - Chong SA
LA  - eng
PT  - Journal Article
DEP - 20120523
PL  - United States
TA  - Acta Psychiatr Scand
JT  - Acta psychiatrica Scandinavica
JID - 0370364
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Early Medical Intervention
MH  - Educational Status
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Marital Status
MH  - Prognosis
MH  - Psychotic Disorders/physiopathology/*therapy
MH  - Recovery of Function
MH  - Remission Induction
MH  - Risk Factors
MH  - Schizophrenia/physiopathology/*therapy
MH  - Sex Factors
MH  - Treatment Outcome
EDAT- 2012/05/24 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 10.1111/j.1600-0447.2012.01883.x [doi]
PST - ppublish
SO  - Acta Psychiatr Scand. 2012 Oct;126(4):282-9. doi: 
      10.1111/j.1600-0447.2012.01883.x. Epub 2012 May 23.