PMID- 22616807
OWN - NLM
STAT- MEDLINE
DCOM- 20121025
LR  - 20120607
IS  - 1432-2277 (Electronic)
IS  - 0934-0874 (Linking)
VI  - 25
IP  - 7
DP  - 2012 Jul
TI  - HHV-6B is frequently found in the gastrointestinal tract in kidney 
      transplantation patients.
PG  - 776-82
LID - 10.1111/j.1432-2277.2012.01502.x [doi]
AB  - In immunosuppressed patients human herpesvirus 6 (HHV-6) reactivations are 
      common. The aim of the study was to determine to which extent HHV-6 can be found 
      in the gastrointestinal tract in kidney transplant recipients and in patients on 
      chronic dialysis. The HHV-6 and cytomegalovirus (CMV) examinations were performed 
      on gastro duodenal and colon biopsy specimens obtained from 81 kidney transplant 
      recipients and on 46 chronic dialysis patients. The HHV-6 and CMV were 
      demonstrated by immunohistochemistry detecting both HHV-6A and HHV-6B, and 
      CMV-specific antigens. The HHV-6B-positive cells, were found in gastroduodenal 
      biopsy specimens from 34% of the transplant recipients and 28% of the patients on 
      chronic dialysis, CMV-positive cells were found in specimens from 53% of the 
      transplant recipients and 28% of the patients on chronic dialysis. The HHV-6B 
      positive cells were found in the colonic mucosa specimens from 36% of the 
      transplant recipients and 22% of the patients on chronic dialysis, CMV-positive 
      cells were found in specimens from 36% of the transplant recipients and 17% of 
      the patients on chronic dialysis. The HHV-6B positive cells were found equally 
      often in the gastroduodenal as in the colorectal mucosa. The HHV-6B positive 
      cells as well as CMV positive cells were simultaneously found in every fifth of 
      transplant recipients.
CI  - (c) 2012 The Authors. Transplant International (c) 2012 European Society for Organ 
      Transplantation.
FAU - Lempinen, Marko
AU  - Lempinen M
AD  - Department of Transplantation and Liver Surgery, and Transplant Unit Research 
      Laboratory, Helsinki University Hospital, Helsinki, Finland. 
      marko.lempinen@hus.fi
FAU - Halme, Leena
AU  - Halme L
FAU - Arola, Johanna
AU  - Arola J
FAU - Honkanen, Eero
AU  - Honkanen E
FAU - Salmela, Kaija
AU  - Salmela K
FAU - Lautenschlager, Irmeli
AU  - Lautenschlager I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120522
PL  - Switzerland
TA  - Transpl Int
JT  - Transplant international : official journal of the European Society for Organ 
      Transplantation
JID - 8908516
RN  - 0 (Antiviral Agents)
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antiviral Agents/pharmacology
MH  - Endoscopy/methods
MH  - Female
MH  - Gastrointestinal Tract/*virology
MH  - Herpesvirus 6, Human/*metabolism
MH  - Humans
MH  - Immunosuppressive Agents/adverse effects
MH  - Intestinal Mucosa/metabolism
MH  - Kidney Transplantation/adverse effects/*methods
MH  - Male
MH  - Middle Aged
MH  - Models, Biological
MH  - Renal Dialysis/methods
MH  - Renal Insufficiency/therapy
EDAT- 2012/05/24 06:00
MHDA- 2012/10/26 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/10/26 06:00 [medline]
AID - 10.1111/j.1432-2277.2012.01502.x [doi]
PST - ppublish
SO  - Transpl Int. 2012 Jul;25(7):776-82. doi: 10.1111/j.1432-2277.2012.01502.x. Epub 
      2012 May 22.