PMID- 22616936
OWN - NLM
STAT- MEDLINE
DCOM- 20130226
LR  - 20211021
IS  - 1440-1843 (Electronic)
IS  - 1323-7799 (Print)
IS  - 1323-7799 (Linking)
VI  - 17
IP  - 7
DP  - 2012 Oct
TI  - Tobacco smoke exposure and allergic sensitization in children: a propensity score 
      analysis.
PG  - 1068-72
LID - 10.1111/j.1440-1843.2012.02201.x [doi]
AB  - BACKGROUND AND OBJECTIVE: There is conflicting evidence of the effect of 
      environmental tobacco smoke (ETS) on the development of allergic diseases in 
      children. Studies have shown that this relationship differs depending on maternal 
      history of the disease. We employed the rigour of propensity score methods to 
      assess this relationship using data from a birth cohort. METHODS: Using n = 662 
      children from the Wayne County Health, Environment, Allergy and Asthma 
      Longitudinal Study, we assessed the relationship between early-life ETS and 
      subsequent allergic sensitization via a positive skin prick test (SPT+) or at 
      least one specific immunoglobulin E (IgE) >/= 0.35 (sIgE+) in children aged 2-3 
      years. Propensity score estimation followed by full and nearest neighbour 
      matching was compared with standard multivariable regression models. RESULTS: 
      Among children without a maternal history of allergic disease, ETS was positively 
      associated with allergic sensitization in children with an adjusted odds ratio 
      (aOR) for SPT+ of 2.32 (95% confidence interval (CI): 1.28-4.22) and the aOR for 
      sIgE+ was 2.53 (95% CI: 1.43-4.48). Contrarily, for children with a positive 
      maternal history, the aOR for SPT+ and sIgE+ was 0.56 (95% CI: 0.24-1.32) and 
      0.43 (95% CI: 0.20-0.91), respectively. CONCLUSIONS: Using propensity score 
      methods to rigorously control for confounding factors, ETS exposure was found to 
      reduce the risk of allergic sensitization in children with a positive maternal 
      history. There is a strong association between early-life ETS and the development 
      of allergic sensitization for children aged 2-3 years without maternal history.
CI  - (c) 2012 The Authors. Respirology (c) 2012 Asian Pacific Society of Respirology.
FAU - Havstad, Suzanne L
AU  - Havstad SL
AD  - Department of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan, 
      USA. shavsta1@hfhs.org
FAU - Johnson, Christine Cole
AU  - Johnson CC
FAU - Zoratti, Edward M
AU  - Zoratti EM
FAU - Ezell, Jerel M
AU  - Ezell JM
FAU - Woodcroft, Kimberly
AU  - Woodcroft K
FAU - Ownby, Dennis R
AU  - Ownby DR
FAU - Wegienka, Ganesa
AU  - Wegienka G
LA  - eng
GR  - R01 AI059415/AI/NIAID NIH HHS/United States
GR  - R21 AI059415/AI/NIAID NIH HHS/United States
GR  - R01AI50681/AI/NIAID NIH HHS/United States
GR  - P01 AI089473/AI/NIAID NIH HHS/United States
GR  - R01 AI050681/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Respirology
JT  - Respirology (Carlton, Vic.)
JID - 9616368
RN  - 0 (Tobacco Smoke Pollution)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - Respirology. 2012 Oct;17(7):1029-30. PMID: 22862887
MH  - Child
MH  - Child, Preschool
MH  - Environmental Exposure/*adverse effects
MH  - Female
MH  - Humans
MH  - Hypersensitivity/epidemiology/*etiology
MH  - Immunization
MH  - Immunoglobulin E
MH  - Male
MH  - Pregnancy
MH  - Propensity Score
MH  - Risk Factors
MH  - Skin Tests
MH  - Smoking/*adverse effects
MH  - Tobacco Smoke Pollution/*adverse effects
PMC - PMC3725576
MID - NIHMS486388
EDAT- 2012/05/24 06:00
MHDA- 2013/02/27 06:00
PMCR- 2013/10/01
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2013/02/27 06:00 [medline]
PHST- 2013/10/01 00:00 [pmc-release]
AID - 10.1111/j.1440-1843.2012.02201.x [doi]
PST - ppublish
SO  - Respirology. 2012 Oct;17(7):1068-72. doi: 10.1111/j.1440-1843.2012.02201.x.