PMID- 22617010
OWN - NLM
STAT- MEDLINE
DCOM- 20121102
LR  - 20220409
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 519
IP  - 1
DP  - 2012 Jun 21
TI  - The concentrations of serum, plasma and platelet BDNF are all increased by 
      treadmill VO(2)max performance in healthy college men.
PG  - 78-83
LID - 10.1016/j.neulet.2012.05.025 [doi]
AB  - The most current human-based studies in which brain-derived neurotrophic factor 
      (BDNF) levels in the peripheral blood system are analyzed use it as an indicator 
      that represents BDNF levels in the CNS. However, whether circulating BDNF (serum 
      and plasma) is positively or inversely associated with cardiorespiratory fitness 
      levels (VO(2max)) is still controversial, and no study has done to investigate 
      exercise effects on the concentration of BDNF stored in circulating platelets 
      which, in fact, store a large amount of circulating BDNF. Thus, the purpose of 
      this study was to determine the relation between VO(2max) and all circulating 
      BDNF levels (serum, plasma and platelets) in college male students (N=18; age, 19 
      +/- 1 years; height, 173.22 +/- 7.65 cm; weight, 78.25 +/- 14.25 kg; body fat percent, 
      13.82 +/- 5.68%). Dual X-ray energy absorptiometry whole body scan was used to 
      measure their body composition. After the overnight fast, all participants were 
      performed VO(2max) test, and their blood was collected at rest and immediately 
      after the exercise. Our data resulted in significant increases in platelet counts 
      and serum, plasma and platelet BDNF levels immediately after the exercise 
      (p<0.01). VO(2max) had a significant negative correlation with serum BDNF, plasma 
      BDNF and platelet BDNF at rest (p<0.05) but a significant positive correlation 
      with serum, plasma BDNF, and platelet BDNF immediately after the exercise 
      (p<0.01). However, our data show no correlation between VO(2max) and platelet 
      count both at rest and immediately after the exercise. In conclusion, this is the 
      first study showing that basal BDNF levels are inversely correlated with 
      cardiorespiratory fitness levels but that the inverse correlations turn into 
      positive correlations with all circulating BDNF levels immediately after the 
      exercise. Moreover, it is the first time to provide evidence that platelet BDNF 
      levels are also positively affected by the exercise. However, future studies will 
      be needed to investigate what tissues provide BDNF into the circulating system 
      and to elucidate the role of circulating BDNF.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Cho, Hyun-Chul
AU  - Cho HC
AD  - Sport & Wellness Research Center & Department of Physical Education, College of 
      Sports Sciences, Yong-in University, Gyeonggi-do, Republic of Korea.
FAU - Kim, Jongkyu
AU  - Kim J
FAU - Kim, Sungyeon
AU  - Kim S
FAU - Son, Yeon Hee
AU  - Son YH
FAU - Lee, Namju
AU  - Lee N
FAU - Jung, Seung Ho
AU  - Jung SH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120514
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Exercise Test
MH  - Humans
MH  - Male
MH  - Physical Endurance/*physiology
MH  - Physical Fitness/*physiology
MH  - *Task Performance and Analysis
MH  - Up-Regulation/physiology
MH  - Young Adult
EDAT- 2012/05/24 06:00
MHDA- 2012/11/03 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/02/23 00:00 [received]
PHST- 2012/04/25 00:00 [revised]
PHST- 2012/05/06 00:00 [accepted]
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/11/03 06:00 [medline]
AID - S0304-3940(12)00661-1 [pii]
AID - 10.1016/j.neulet.2012.05.025 [doi]
PST - ppublish
SO  - Neurosci Lett. 2012 Jun 21;519(1):78-83. doi: 10.1016/j.neulet.2012.05.025. Epub 
      2012 May 14.