PMID- 22617481
OWN - NLM
STAT- MEDLINE
DCOM- 20121016
LR  - 20181030
IS  - 1525-1438 (Electronic)
IS  - 1048-891X (Linking)
VI  - 22
IP  - 5
DP  - 2012 Jun
TI  - Tumor-infiltrating dendritic cells may be used as clinicopathologic prognostic 
      factors in endometrial carcinoma.
PG  - 836-41
LID - 10.1097/IGC.0b013e31825401c6 [doi]
AB  - OBJECTIVE: To investigate the distribution of dendritic cells (DCs) at different 
      development status in endometrial carcinoma and their relationship with clinical 
      pathology. METHODS: Samples were collected from 95 patients with endometrial 
      endometrioid adenocarcinoma treated in Peking University People's Hospital from 
      2002 to 2010. Normal endometrial tissue was obtained from 40 women and served as 
      controls. Immunohistochemistry was used to detect the expression of S100-, human 
      leukocyte antigen (HLA)-DR-, and CD1a-positive DCs within the tumor glandular 
      epithelium, the surrounding tumor interstitial tissue, and the equivalent normal 
      endometrial tissue. The relationship of these DCs with clinical stage, pathology 
      grade, myometrial invasion, and lymph node metastasis was analyzed. RESULTS: The 
      rate of S100-positive DCs in the endometrial endometrioid adenocarcinoma 
      glandular epithelium samples from the 95 patients was 48.4% (46/95), and that of 
      the HLA-DR-positive DCs was 27.4% (26/95), which were both significantly higher 
      (P < 0.05) than that in the control group. CD1a-positive DC was rarely expressed 
      in endometrial endometrioid adenocarcinoma glandular epithelium. The rates of the 
      S100- and HLA-DR-positive DCs in tumor interstitial tissue were similar to that 
      of the control group (both, P > 0.05). The proportion of invasion of the S100- 
      and HLA-DR-positive DCs was negatively correlated with the clinical stage and 
      lymph node metastasis but was not correlated with the pathological grade and 
      myometrial invasion. CONCLUSIONS: Dendritic cell invasion was detected in 
      endometrial endometrioid adenocarcinoma. S100- and HLA-DR-positive DCs may have 
      functions related to the delay of tumor progression and lymph node metastasis.
FAU - Lijun, Zhao
AU  - Lijun Z
AD  - Department of Obstetrics and Gynecology, Peking University People's Hospital, 
      Beijing, China.
FAU - Xin, Zhao
AU  - Xin Z
FAU - Danhua, Shen
AU  - Danhua S
FAU - Xiaoping, Li
AU  - Xiaoping L
FAU - Jianliu, Wang
AU  - Jianliu W
FAU - Huilan, Wang
AU  - Huilan W
FAU - Lihui, Wei
AU  - Lihui W
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Gynecol Cancer
JT  - International journal of gynecological cancer : official journal of the 
      International Gynecological Cancer Society
JID - 9111626
RN  - 0 (HLA-DR Antigens)
RN  - 0 (S100 Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Endometrioid/immunology/metabolism/*pathology
MH  - Case-Control Studies
MH  - Dendritic Cells/*immunology/metabolism/*pathology
MH  - Endometrial Neoplasms/immunology/metabolism/*pathology
MH  - Endometrium/immunology/metabolism/*pathology
MH  - Female
MH  - HLA-DR Antigens/metabolism
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Lymphatic Metastasis
MH  - Middle Aged
MH  - Myometrium/immunology/metabolism/*pathology
MH  - Neoplasm Invasiveness
MH  - Neoplasm Staging
MH  - Prognosis
MH  - S100 Proteins/metabolism
MH  - Survival Rate
EDAT- 2012/05/24 06:00
MHDA- 2012/10/17 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/10/17 06:00 [medline]
AID - 10.1097/IGC.0b013e31825401c6 [doi]
PST - ppublish
SO  - Int J Gynecol Cancer. 2012 Jun;22(5):836-41. doi: 10.1097/IGC.0b013e31825401c6.