PMID- 22617823
OWN - NLM
STAT- MEDLINE
DCOM- 20120906
LR  - 20191210
IS  - 1531-6963 (Electronic)
IS  - 1040-8711 (Linking)
VI  - 24
IP  - 4
DP  - 2012 Jul
TI  - Infections and vaccines in the etiology of antiphospholipid syndrome.
PG  - 389-93
LID - 10.1097/BOR.0b013e32835448b8 [doi]
AB  - PURPOSE OF REVIEW: To present scientific evidence supporting the infectious 
      origin for the antiphospholipid syndrome (APS) by molecular mimicry between 
      pathogens, infection and vaccination with beta2-glycoprotein I (beta2-GPI) molecule. 
      RECENT FINDINGS: APS is characterized by the presence of pathogenic 
      autoantibodies against beta2-GPI. The infection etiology of APS was well 
      established. Likewise, a link between vaccination such as tetanus toxoid may 
      trigger antibodies targeting tetanus toxoid and beta2-GPI, due to molecular mimicry 
      between the two molecules. During the years, the pathogenic potential of 
      anti-tetanus toxoid antibodies cross reactive with beta2-GPI were found to be 
      pathogenic in animal models, inducing experimental APS. SUMMARY: Accumulated 
      evidence supports that the presence of anti-beta2-GPI antibodies is associated with 
      a history of infections and the main mechanism to explain this correlation is 
      molecular mimicry. The relationship between tetanus toxoid vaccination and APS 
      reveals a novel view on the autoimmune/autoinflammatory syndrome induced by 
      adjuvants (ASIA).
FAU - Cruz-Tapias, Paola
AU  - Cruz-Tapias P
AD  - Zabludowitz Center for Autoimmune Diseases, Sheba Medical Center affiliated to 
      Sackler Faculty of Medicine, Tel-Aviv University, Israel.
FAU - Blank, Miri
AU  - Blank M
FAU - Anaya, Juan-Manuel
AU  - Anaya JM
FAU - Shoenfeld, Yehuda
AU  - Shoenfeld Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Rheumatol
JT  - Current opinion in rheumatology
JID - 9000851
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Autoantibodies)
RN  - 0 (Tetanus Toxoid)
RN  - 0 (beta 2-Glycoprotein I)
SB  - IM
MH  - Adjuvants, Immunologic/adverse effects
MH  - Antiphospholipid Syndrome/*etiology/immunology
MH  - Autoantibodies/biosynthesis
MH  - Cross Reactions/immunology
MH  - Humans
MH  - Infections/*complications
MH  - Molecular Mimicry
MH  - Tetanus Toxoid/*adverse effects
MH  - beta 2-Glycoprotein I/immunology
EDAT- 2012/05/24 06:00
MHDA- 2012/09/07 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/09/07 06:00 [medline]
AID - 10.1097/BOR.0b013e32835448b8 [doi]
PST - ppublish
SO  - Curr Opin Rheumatol. 2012 Jul;24(4):389-93. doi: 10.1097/BOR.0b013e32835448b8.