PMID- 22618665
OWN - NLM
STAT- MEDLINE
DCOM- 20121018
LR  - 20220330
IS  - 1613-2246 (Electronic)
IS  - 0021-5155 (Linking)
VI  - 56
IP  - 4
DP  - 2012 Jul
TI  - Estimating retinal nerve fiber layer thickness in normal schoolchildren with 
      spectral-domain optical coherence tomography.
PG  - 362-70
LID - 10.1007/s10384-012-0142-7 [doi]
AB  - PURPOSE: To measure the peripapillary retinal nerve fiber layer (RNFL) thickness 
      in normal schoolchildren with spectral domain optical coherence tomography 
      (SD-OCT), and to evaluate the effects of age, spherical equivalent (SE) 
      refraction, OCT signal strength, and cycloplegic treatment on RNFL thickness. 
      METHODS: Comprehensive ophthalmic examinations were performed at a school visit. 
      RNFL thicknesses were measured with RTVue-100 OCT. Refractive errors were 
      measured by cycloplegic autorefraction. RESULTS: Four hundred seventy healthy 
      schoolchildren aged 7 and 12 were enrolled. The average RNFL thickness (mean +/- 
      SD) was 109.4 +/- 10.0 mum. The quadrant RNFL thicknesses were 90.4 +/- 14.3 mum 
      (temporal), 142.2 +/- 19.5 mum (inferior), 71.1 +/- 11.3 mum (nasal), and 133.9 +/- 18.1 
      mum (superior). After controlling for age, gender, cycloplegic treatment, and 
      signal strength index, multiple linear regression analysis disclosed that only SE 
      refraction has a significant effect on RNFL thickness, (p < 0.001). For every 
      diopter change towards hyperopia, the average RNFL thickness increased by 1.7 mum. 
      SE refraction was positively correlated with RNFL thickness in most sectors of 
      nontemporal quadrants, but it was negatively correlated with RNFL thickness in 
      sectors of temporal quadrants. CONCLUSIONS: Our study provides reference values 
      of pediatric RNFL thickness measured with SD-OCT. SE refraction is the only 
      significant predictor of RNFL thickness.
FAU - Tsai, Der-Chong
AU  - Tsai DC
AD  - Department of Ophthalmology, National Yang-Ming University Hospital, Yilan, 
      Taiwan, ROC.
FAU - Huang, Nicole
AU  - Huang N
FAU - Hwu, Jinn-Jong
AU  - Hwu JJ
FAU - Jueng, Ruo-Nan
AU  - Jueng RN
FAU - Chou, Pesus
AU  - Chou P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120523
PL  - Japan
TA  - Jpn J Ophthalmol
JT  - Japanese journal of ophthalmology
JID - 0044652
SB  - IM
MH  - Aging/physiology
MH  - *Axons
MH  - Cell Size
MH  - Child
MH  - Female
MH  - Humans
MH  - Intraocular Pressure
MH  - Male
MH  - Optic Disk/*cytology
MH  - Reference Values
MH  - Refraction, Ocular/physiology
MH  - Refractive Errors/physiopathology
MH  - Retinal Ganglion Cells/*cytology
MH  - *Tomography, Optical Coherence
MH  - Visual Acuity/physiology
EDAT- 2012/05/24 06:00
MHDA- 2012/10/19 06:00
CRDT- 2012/05/24 06:00
PHST- 2011/11/06 00:00 [received]
PHST- 2012/03/26 00:00 [accepted]
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/10/19 06:00 [medline]
AID - 10.1007/s10384-012-0142-7 [doi]
PST - ppublish
SO  - Jpn J Ophthalmol. 2012 Jul;56(4):362-70. doi: 10.1007/s10384-012-0142-7. Epub 
      2012 May 23.