PMID- 22619078
OWN - NLM
STAT- MEDLINE
DCOM- 20121023
LR  - 20220408
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 35
IP  - 7
DP  - 2012 Jul
TI  - Toenail selenium and incidence of type 2 diabetes in U.S. men and women.
PG  - 1544-51
LID - 10.2337/dc11-2136 [doi]
AB  - OBJECTIVE: Compelling biological pathways suggest that selenium (Se) may lower 
      onset of type 2 diabetes mellitus (T2DM), but very few studies have evaluated 
      this relationship, with mixed results. We examined the association between 
      toenail Se and incidence of T2DM. RESEARCH DESIGN AND METHODS: We performed 
      prospective analyses in two separate U.S. cohorts, including 3,630 women and 
      3,535 men, who were free of prevalent T2DM and heart disease at baseline in 
      1982-1983 and 1986-1987, respectively. Toenail Se concentration was quantified 
      using neutron activation analysis, and diabetes cases were identified by biennial 
      questionnaires and confirmed by a detailed supplementary questionnaire. Hazard 
      ratios of incident T2DM according to Se levels were calculated using Cox 
      proportional hazards. RESULTS: During 142,550 person-years of follow-up through 
      2008, 780 cases of incident T2DM occurred. After multivariable adjustment, the 
      risk of T2DM was lower across increasing quintiles of Se, with pooled relative 
      risks across the two cohorts of 1.0 (reference), 0.91 (95% CI 0.73-1.14), 0.78 
      (0.62-0.99), 0.72 (0.57-0.91), and 0.76 (0.60-0.97), respectively (P for trend = 
      0.01). Results were similar excluding the few individuals (4%) who used Se 
      supplements. In semiparametric analyses, the inverse relationship between Se 
      levels and T2DM risk appeared to be linear. CONCLUSIONS: At dietary levels of 
      intake, individuals with higher toenail Se levels are at lower risk for T2DM. 
      Further research is required to determine whether varying results in this study 
      versus prior trials relate to differences in dose, source, statistical power, 
      residual confounding factors, or underlying population risk.
FAU - Park, Kyong
AU  - Park K
AD  - Department of Food & Nutrition, Yeungnam University, Gyeongbuk, Republic of 
      Korea. kypark@ynu.ac.kr
FAU - Rimm, Eric B
AU  - Rimm EB
FAU - Siscovick, David S
AU  - Siscovick DS
FAU - Spiegelman, Donna
AU  - Spiegelman D
FAU - Manson, JoAnn E
AU  - Manson JE
FAU - Morris, J Steven
AU  - Morris JS
FAU - Hu, Frank B
AU  - Hu FB
FAU - Mozaffarian, Dariush
AU  - Mozaffarian D
LA  - eng
GR  - P01 CA055075/CA/NCI NIH HHS/United States
GR  - CA55075/CA/NCI NIH HHS/United States
GR  - HL35464/HL/NHLBI NIH HHS/United States
GR  - R01-ES014433/ES/NIEHS NIH HHS/United States
GR  - R01 HL035464/HL/NHLBI NIH HHS/United States
GR  - R01 ES014433/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120522
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Adult
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology/etiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Nails/*chemistry
MH  - Neutron Activation Analysis
MH  - Prospective Studies
MH  - Selenium/*analysis
PMC - PMC3379617
EDAT- 2012/05/24 06:00
MHDA- 2012/10/24 06:00
PMCR- 2013/07/01
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/10/24 06:00 [medline]
PHST- 2013/07/01 00:00 [pmc-release]
AID - dc11-2136 [pii]
AID - 2136 [pii]
AID - 10.2337/dc11-2136 [doi]
PST - ppublish
SO  - Diabetes Care. 2012 Jul;35(7):1544-51. doi: 10.2337/dc11-2136. Epub 2012 May 22.