PMID- 22619129
OWN - NLM
STAT- MEDLINE
DCOM- 20120914
LR  - 20220309
IS  - 1097-0339 (Electronic)
IS  - 1097-0339 (Linking)
VI  - 40
IP  - 6
DP  - 2012 Jun
TI  - Molecular genetic characterization of lymphoma: application to cytology 
      diagnosis.
PG  - 542-55
LID - 10.1002/dc.22819 [doi]
AB  - Mature B- and T-cell lymphomas are increasingly being associated with specific 
      genetic alterations; characterization of these changes can sometimes be crucial 
      to both diagnosis and prognosis. Molecular testing encompasses fluorescence in 
      situ hybridization (FISH) and polymerase chain reaction (PCR)-based assays, as 
      well as classical cytogenetics. FISH and PCR-based assays can be performed on 
      cytology material without the need for advanced planning for testing with fresh 
      tissue. As many lymphoproliferations are amenable to fine needle aspiration 
      diagnosis, it is important for the cytopathologist to be aware of what testing is 
      feasible in these (sometimes limited) specimens. Here, we review pertinent 
      genetic changes in mature B- and T-cell lymphomas with a focus on those that may 
      be encountered more commonly in cytology specimens.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Ochs, Rachel C
AU  - Ochs RC
AD  - Department of Pathology and Laboratory Medicine, Hospital of the University of 
      Pennsylvania, Philadelphia, Pennsylvania, USA.
FAU - Bagg, Adam
AU  - Bagg A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Diagn Cytopathol
JT  - Diagnostic cytopathology
JID - 8506895
RN  - 0 (BCL6 protein, human)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (MYC protein, human)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (Proto-Oncogene Proteins c-bcl-6)
RN  - 0 (Proto-Oncogene Proteins c-myc)
SB  - IM
MH  - Cell Proliferation
MH  - Chromosomes, Human/genetics
MH  - Cytodiagnosis/*methods
MH  - DNA-Binding Proteins/genetics
MH  - Early Detection of Cancer/methods
MH  - Humans
MH  - Immunohistochemistry
MH  - Lymphoma, B-Cell/*diagnosis/genetics/pathology
MH  - Lymphoma, T-Cell/*diagnosis/genetics/pathology
MH  - Proto-Oncogene Proteins c-bcl-2/genetics
MH  - Proto-Oncogene Proteins c-bcl-6
MH  - Proto-Oncogene Proteins c-myc/genetics
MH  - Sensitivity and Specificity
MH  - Thyroid Neoplasms/diagnosis/genetics/pathology
MH  - Translocation, Genetic
EDAT- 2012/05/24 06:00
MHDA- 2012/09/15 06:00
CRDT- 2012/05/24 06:00
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/09/15 06:00 [medline]
AID - 10.1002/dc.22819 [doi]
PST - ppublish
SO  - Diagn Cytopathol. 2012 Jun;40(6):542-55. doi: 10.1002/dc.22819.