PMID- 22619677
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1687-8469 (Electronic)
IS  - 1687-8450 (Print)
IS  - 1687-8450 (Linking)
VI  - 2012
DP  - 2012
TI  - Altered p16(INK4) and RB1 Expressions Are Associated with Poor Prognosis in 
      Patients with Nonsmall Cell Lung Cancer.
PG  - 957437
LID - 10.1155/2012/957437 [doi]
LID - 957437
AB  - p16(INK4) and RB1 are two potent cell cycle regulators to control the G1/S 
      transition by interacting with CDK4/6, E2F, and D-type cyclins, respectively. 
      Depending on the tumour type, genetic alterations resulting in the functional 
      inactivation have frequently been reported in both genes. By contrast, much less 
      is known regarding the overexpression of these proteins in the tumor cells. In 
      this study, expressions of p16(INK4) RB1, and CDKN2A copy number variances (CNV) 
      in the tumor cells were assessed by immunohistochemistry and fluorescence in situ 
      hybridization (FISH), respectively, in 73 nonsmall cell lung cancer (NSCLC) with 
      known 5-year survivals. The histologic type (P = 0.01), p16(INK4) (P = 0.004), 
      and RB1 (P < 0.001) were predictive of survivals. The CDKN2A CNV (P < 0.05) was 
      also significant when compared to those cases without CNV. Therefore, among the 
      molecular genetic prognostic factors, expressions of RB1 and p16(INK4) in the 
      tumor cells were the most strongly predictive of adverse outcomes in stage I and 
      II nonsquamous NSCLC.
FAU - Zhao, Weiqiang
AU  - Zhao W
AD  - Department of Pathology, The Ohio State University Medical Center, Columbus, OH 
      43210, USA.
FAU - Huang, Cheng C
AU  - Huang CC
FAU - Otterson, Gregory A
AU  - Otterson GA
FAU - Leon, Marino E
AU  - Leon ME
FAU - Tang, Yan
AU  - Tang Y
FAU - Shilo, Konstantin
AU  - Shilo K
FAU - Villalona, Miguel A
AU  - Villalona MA
LA  - eng
PT  - Journal Article
DEP - 20120430
PL  - Egypt
TA  - J Oncol
JT  - Journal of oncology
JID - 101496537
PMC - PMC3350860
EDAT- 2012/05/24 06:00
MHDA- 2012/05/24 06:01
PMCR- 2012/04/30
CRDT- 2012/05/24 06:00
PHST- 2011/10/27 00:00 [received]
PHST- 2012/02/06 00:00 [revised]
PHST- 2012/02/14 00:00 [accepted]
PHST- 2012/05/24 06:00 [entrez]
PHST- 2012/05/24 06:00 [pubmed]
PHST- 2012/05/24 06:01 [medline]
PHST- 2012/04/30 00:00 [pmc-release]
AID - 10.1155/2012/957437 [doi]
PST - ppublish
SO  - J Oncol. 2012;2012:957437. doi: 10.1155/2012/957437. Epub 2012 Apr 30.