PMID- 22621386
OWN - NLM
STAT- MEDLINE
DCOM- 20121010
LR  - 20160511
IS  - 1945-0257 (Electronic)
IS  - 1945-0257 (Linking)
VI  - 16
IP  - 5
DP  - 2012 May
TI  - HLA B27 subtype distribution among patients with ankylosing spondylitis in 
      eastern Turkey.
PG  - 456-8
LID - 10.1089/gtmb.2011.0183 [doi]
AB  - Human leukocyte antigen (HLA) B27 has a strong association with ankylosing 
      spondylitis (AS) and other spondyloarthropathies. More than 70 subtypes of HLA 
      B27 have been described. The present study investigated B27 subtype distribution 
      among B27-positive patients with AS classified according to the modified New York 
      criteria and healthy controls. Sequence-specific primer polymerase chain reaction 
      technique was used for B27 subtyping of 43 unrelated patients with AS and 39 
      volunteer bone marrow donors. Among patients with AS, the male-female ratio was 
      6.2 and the mean age was 30 years. No relationship was found between the B27 
      subtypes and clinical and laboratory findings in patients with AS (p>0.05). 
      Similarly, the frequencies of B27 subtypes did not significantly differ between 
      patients and controls. In this study, B*2746, B*2749, and B*2767 subtypes were 
      detected for the first time. Among B27 subtypes, the most common B27 alleles 
      found in the patients and the controls were B*2702 and B*2705. In addition, 
      B*2702 subtype was found predominantly in both patients (48.8%) and controls 
      (46.2%). In conclusion, in addition to commonly encountered B*2702 and B*2705 HLA 
      subtypes, a B*2749 subtype in a patient with AS and B*2746 as well as B*2767 
      subtypes in controls were determined for the first time.
FAU - Diyarbakir, Eda
AU  - Diyarbakir E
AD  - Faculty of Medicine, Department of Medical Biology, Ataturk University, Erzurum, 
      Turkey.
FAU - Eyerci, Nilnur
AU  - Eyerci N
FAU - Melikoglu, Meltem
AU  - Melikoglu M
FAU - Topcu, Atilla
AU  - Topcu A
FAU - Pirim, Ibrahim
AU  - Pirim I
LA  - eng
PT  - Journal Article
DEP - 20120321
PL  - United States
TA  - Genet Test Mol Biomarkers
JT  - Genetic testing and molecular biomarkers
JID - 101494210
RN  - 0 (HLA-B*27:05 antigen)
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Female
MH  - *Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - HLA-B27 Antigen/*classification/*genetics/immunology
MH  - Humans
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Spondylitis, Ankylosing/*genetics/immunology
MH  - Turkey/epidemiology
MH  - Young Adult
EDAT- 2012/05/25 06:00
MHDA- 2012/10/12 06:00
CRDT- 2012/05/25 06:00
PHST- 2012/05/25 06:00 [entrez]
PHST- 2012/05/25 06:00 [pubmed]
PHST- 2012/10/12 06:00 [medline]
AID - 10.1089/gtmb.2011.0183 [doi]
PST - ppublish
SO  - Genet Test Mol Biomarkers. 2012 May;16(5):456-8. doi: 10.1089/gtmb.2011.0183. 
      Epub 2012 Mar 21.