PMID- 22621764
OWN - NLM
STAT- MEDLINE
DCOM- 20130418
LR  - 20211021
IS  - 1748-717X (Electronic)
IS  - 1748-717X (Linking)
VI  - 7
DP  - 2012 May 23
TI  - Acute gastrointestinal and genitourinary toxicity of image-guided intensity 
      modulated radiation therapy for prostate cancer using a daily water-filled 
      endorectal balloon.
PG  - 76
LID - 10.1186/1748-717X-7-76 [doi]
AB  - BACKGROUND: Our purpose was to report acute gastrointestinal (GI) and 
      genitourinary (GU) toxicity rates for prostate cancer patients undergoing 
      image-guided intensity modulated radiation therapy (IG-IMRT) with a daily 
      endorectal water-filled balloon (ERBH2O), and assess associations with planning 
      parameters and pretreatment clinical characteristics. METHODS: The first 100 
      patients undergoing prostate and proximal seminal vesicle IG-IMRT with 
      indexed-lumen 100 cc ERBH2O to 79.2 Gy in 1.8 Gy fractions at our institution 
      from 12/2008- 12/2010 were assessed. Pretreatment characteristics, organ-at-risk 
      dose volume histograms, and maximum GU and GI toxicities (CTCAE 3.0) were 
      evaluated. Logistic regression models evaluated univariate association between 
      toxicities and dosimetric parameters, and uni- and multivariate association 
      between toxicities and pretreatment characteristics. RESULTS: Mean age was 68 
      (range 51-88). Thirty-two, 49, and 19 patients were low, intermediate, and 
      high-risk, respectively; 40 received concurrent androgen deprivation. No grade 3 
      or greater toxicities were recorded. Maximum GI toxicity was grade 0, 1, and 2 in 
      69%, 23%, and 8%, respectively. Infield (defined as 1 cm above/below the CTV) 
      rectal mean/median doses, D75, V30, and V40 and hemorrhoid history were 
      associated with grade 2 GI toxicity (Ps < 0.05). Maximum acute GU toxicity was 
      grade 0, 1, and 2 for 17%, 41%, and 42% of patients, respectively. Infield 
      bladder V20 (P = 0.03) and pretreatment International Prostate Symptom Scale 
      (IPSS) (P = 0.003) were associated with grade 2 GU toxicity. CONCLUSION: Prostate 
      IG-IMRT using a daily ERBH2O shows low rates of acute GI toxicity compared to 
      previous reports of air-filled ERB IMRT when using stringent infield rectum 
      constraints and comparable GU toxicities.
FAU - Deville, Curtiland
AU  - Deville C
AD  - Department of Radiation Oncology, Pennsylvania, USA. deville@uphs.upenn.edu
FAU - Both, Stefan
AU  - Both S
FAU - Bui, Viet
AU  - Bui V
FAU - Hwang, Wei-Ting
AU  - Hwang WT
FAU - Tan, Kay-See
AU  - Tan KS
FAU - Schaer, Mattia
AU  - Schaer M
FAU - Tochner, Zelig
AU  - Tochner Z
FAU - Vapiwala, Neha
AU  - Vapiwala N
LA  - eng
PT  - Journal Article
DEP - 20120523
PL  - England
TA  - Radiat Oncol
JT  - Radiation oncology (London, England)
JID - 101265111
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Gastrointestinal Tract/radiation effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prostatic Neoplasms/*radiotherapy
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted
MH  - Radiotherapy, Image-Guided/*adverse effects/*methods
MH  - Radiotherapy, Intensity-Modulated/*adverse effects/*methods
MH  - Retrospective Studies
MH  - Urogenital System/radiation effects
PMC - PMC3464898
EDAT- 2012/05/25 06:00
MHDA- 2013/04/20 06:00
PMCR- 2012/05/23
CRDT- 2012/05/25 06:00
PHST- 2012/03/11 00:00 [received]
PHST- 2012/05/06 00:00 [accepted]
PHST- 2012/05/25 06:00 [entrez]
PHST- 2012/05/25 06:00 [pubmed]
PHST- 2013/04/20 06:00 [medline]
PHST- 2012/05/23 00:00 [pmc-release]
AID - 1748-717X-7-76 [pii]
AID - 10.1186/1748-717X-7-76 [doi]
PST - epublish
SO  - Radiat Oncol. 2012 May 23;7:76. doi: 10.1186/1748-717X-7-76.