PMID- 22621796
OWN - NLM
STAT- MEDLINE
DCOM- 20121018
LR  - 20151119
IS  - 1879-1913 (Electronic)
IS  - 0002-9149 (Linking)
VI  - 110
IP  - 5
DP  - 2012 Sep 1
TI  - Evaluation of low-density lipoprotein particle number distribution in patients 
      with type 2 diabetes mellitus with low-density lipoprotein cholesterol <50 mg/dl 
      and non-high-density lipoprotein cholesterol <80 mg/dl.
PG  - 662-5
LID - 10.1016/j.amjcard.2012.04.046 [doi]
AB  - Many patients with type 2 diabetes mellitus (T2DM) have relatively normal levels 
      of low-density lipoprotein (LDL) cholesterol yet have increased risk for 
      cardiovascular events. Distribution of lipoprotein subclasses in patients with 
      T2DM who have achieved very low levels of LDL cholesterol (<50 mg/dl) or 
      non-high-density lipoprotein (HDL) cholesterol (<80 mg/dl) have not been 
      extensively examined. The aim of this study was to assess variations in 
      lipoprotein particle concentration in patients with diabetes with "very low" LDL 
      cholesterol and non-HDL cholesterol levels to elucidate the drivers of residual 
      cardiovascular risk. Data were selected from a single large clinical laboratory 
      database. Cases were patients with T2DM diagnosis codes (International 
      Classification of Diseases, Ninth Revision, codes 250 to 250.93). Lipoprotein 
      particle concentrations were analyzed using nuclear magnetic resonance 
      spectroscopy. The Friedewald equation was used to calculate LDL cholesterol. 
      Among the 1,970 patients with T2DM, the mean age was 61 years, and approximately 
      51% were men. At LDL cholesterol concentrations <50 mg/dl (triglyceride <150 
      mg/dl and HDL cholesterol >40 mg/dl), 16% had LDL particle concentrations <500 
      nmol/L, 70% had concentrations of 500 to 1,000 nmol/L, and 14% had concentrations 
      >1,001 nmol/L. At non-HDL cholesterol levels <80 mg/dl, 8% had LDL particle 
      concentrations <500 nmol/L, 67% had concentrations of 500 to 1,000 nmol/L, and 
      25% had concentrations >1,001 nmol/L. In conclusion, despite attainment of LDL 
      cholesterol <50 mg/dl or non-HDL cholesterol <80 mg/dl, patients with diabetes 
      exhibited significant variation in LDL particle levels, with most having LDL 
      particle concentrations >500 nmol/L, suggesting the persistence of potential 
      residual coronary heart disease risk.
CI  - Copyright (c) 2012. Published by Elsevier Inc.
FAU - Malave, Hector
AU  - Malave H
AD  - Cardiology of Atlanta, Atlanta, Georgia, USA. hmalave@cardioatl.com
FAU - Castro, Manuel
AU  - Castro M
FAU - Burkle, Jaime
AU  - Burkle J
FAU - Voros, Szilard
AU  - Voros S
FAU - Dayspring, Thomas
AU  - Dayspring T
FAU - Honigberg, Robert
AU  - Honigberg R
FAU - Pourfarzib, Ray
AU  - Pourfarzib R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120522
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Biomarkers)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Biomarkers/blood
MH  - Cholesterol, HDL/blood
MH  - Cholesterol, LDL/*blood
MH  - Cohort Studies
MH  - Coronary Artery Disease/*diagnosis/epidemiology
MH  - Databases, Factual
MH  - Diabetes Mellitus, Type 2/*blood/diagnosis/epidemiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Lipoproteins, LDL/*blood
MH  - Magnetic Resonance Spectroscopy
MH  - Male
MH  - Middle Aged
MH  - Particle Size
MH  - Prognosis
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Sex Distribution
MH  - Triglycerides/blood
EDAT- 2012/05/25 06:00
MHDA- 2012/10/19 06:00
CRDT- 2012/05/25 06:00
PHST- 2012/01/18 00:00 [received]
PHST- 2012/04/26 00:00 [revised]
PHST- 2012/04/26 00:00 [accepted]
PHST- 2012/05/25 06:00 [entrez]
PHST- 2012/05/25 06:00 [pubmed]
PHST- 2012/10/19 06:00 [medline]
AID - S0002-9149(12)01243-X [pii]
AID - 10.1016/j.amjcard.2012.04.046 [doi]
PST - ppublish
SO  - Am J Cardiol. 2012 Sep 1;110(5):662-5. doi: 10.1016/j.amjcard.2012.04.046. Epub 
      2012 May 22.