PMID- 22624445
OWN - NLM
STAT- MEDLINE
DCOM- 20120614
LR  - 20120525
IS  - 1565-1088 (Print)
VI  - 14
IP  - 1
DP  - 2012 Jan
TI  - Oral desensitization for immunoglobulin E-mediated milk and egg allergies.
PG  - 53-6
AB  - Food allergy is an increasingly prevalent disease in western countries, but an 
      effective form of therapy has not yet been found. A specific active treatment for 
      immunoglobulin E (IgE)-mediated food allergy is currently under study in human 
      clinical trials. Allergen-specific approaches include oral, sublingual and 
      epicutaneous immunotherapy. Currently, reports on oral immunotherapy (OIT) have 
      been more extensive than reports on other routes such as sublingual immunotherapy 
      (SLIT) and epicutaneous patch. The aim of OIT using foods, especially milk and 
      egg--the cause of most common allergies in infants and young children in 
      Europe--is the achievement of desensitization or tolerance by patients suffering 
      from food allergy. Treatment protocols have been initiated in highly supervised 
      research settings with the goal of finding an active treatment against 
      IgE-mediated food allergy. The preliminary data on OIT are encouraging, and among 
      the plethora of novel approaches the strategies most likely to advance into 
      clinical practice include both OIT and SLIT. It is still unclear whether oral 
      desensitization is only the first step toward permanent desensitization or 
      whether it induces only a transient tolerance. Longer duration of desensitization 
      may result in permanent tolerance. The occurrence of adverse events or reactions 
      during OIT is quite frequent and has been reported in all published studies. 
      Therefore, before this treatment can be used in clinical practice additional 
      studies are needed. Currently, immunotherapy for cow's milk or egg allergies is a 
      novel approach that expands the possibility of an active treatment to improve the 
      quality of life of patients and their families.
FAU - Crisafulli, Giuseppe
AU  - Crisafulli G
AD  - Department of Pediatrics, Allergy Unit, University of Messina, Italy.
FAU - Caminiti, Lucia
AU  - Caminiti L
FAU - Pajno, Giovanni B
AU  - Pajno GB
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Israel
TA  - Isr Med Assoc J
JT  - The Israel Medical Association journal : IMAJ
JID - 100930740
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Administration, Oral
MH  - Allergens/administration & dosage
MH  - Desensitization, Immunologic/*methods
MH  - Egg Hypersensitivity/*therapy
MH  - Humans
MH  - Immune Tolerance
MH  - Immunoglobulin E/immunology
MH  - Milk Hypersensitivity/immunology/*therapy
MH  - Treatment Outcome
EDAT- 2012/05/26 06:00
MHDA- 2012/06/15 06:00
CRDT- 2012/05/26 06:00
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/06/15 06:00 [medline]
PST - ppublish
SO  - Isr Med Assoc J. 2012 Jan;14(1):53-6.