PMID- 22624655
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20220317
IS  - 1744-2818 (Electronic)
IS  - 1350-6129 (Linking)
VI  - 19
IP  - 3
DP  - 2012 Sep
TI  - Anxiety and depression among AL amyloidosis patients: the role of cardiac 
      symptoms.
PG  - 123-8
LID - 10.3109/13506129.2012.687420 [doi]
AB  - Light-chain (AL) amyloidosis has the worst prognosis out of the different forms 
      of cardiac amyloidosis, However, data are not available about the incidence of 
      the disease-related psychological impact of AL amyloidosis in this population. In 
      particular, no data are available about the impact of diagnosis communication or 
      about the impact of cardiac symptom onset and severity on anxiety and depression 
      levels among AL patients. AIM: To evaluate the role of time that has passed since 
      the diagnosis was communicated, time that has passed since the onset of cardiac 
      symptoms, and actual cardiac symptom severity have on level of anxiety, 
      depression and psychological stress among cardiology patients with AL. Thirty-two 
      AL patients with cardiac-related symptoms were administered General Health 
      Questionnaire, State-Trait Anxiety Inventory and Centre for Epidemiological 
      Study-Depression Scale. Clinical variables such as months gone by since 
      diagnosis, months gone by since the onset of cardiac symptoms, and cardiac 
      symptom severity (New York Heart Association (NYHA) class) were measured. 
      Troponin, NT-pro BNP levels, Mayo Stage and echocardiographic characteristics 
      were also collected. RESULTS: According to questionnaire normative values, AL 
      patients presented severe psychological distress, severe anxiety and clinical 
      depression. Moreover, anxiety levels were determined by psychological distress (p 
      < 0.001) and months gone by since the onset of cardiac symptoms (p < 0.01) while 
      depression levels were influenced by NYHA class (p < 0.001). CONCLUSIONS: Our 
      results suggest that there is a need to plan psychological support for these 
      patients with consideration for the onset of cardiac symptoms and symptom 
      severity.
FAU - Smorti, Martina
AU  - Smorti M
AD  - Faculty of Education, Free University of Bolzano, Bressanone, Italy. 
      martina.smorti@unibz.it
FAU - Cappelli, Francesco
AU  - Cappelli F
FAU - Bergesio, Franco
AU  - Bergesio F
FAU - Perfetto, Federico
AU  - Perfetto F
LA  - eng
PT  - Journal Article
DEP - 20120525
PL  - England
TA  - Amyloid
JT  - Amyloid : the international journal of experimental and clinical investigation : 
      the official journal of the International Society of Amyloidosis
JID - 9433802
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Amyloidosis/complications/*diagnosis/epidemiology
MH  - Anxiety/*diagnosis/epidemiology/etiology
MH  - Depression/*diagnosis/epidemiology/etiology
MH  - Female
MH  - Heart Diseases/complications/*diagnosis/epidemiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Statistics, Nonparametric
MH  - Stress, Psychological/*diagnosis/epidemiology/etiology
MH  - Surveys and Questionnaires
EDAT- 2012/05/26 06:00
MHDA- 2012/12/18 06:00
CRDT- 2012/05/26 06:00
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
AID - 10.3109/13506129.2012.687420 [doi]
PST - ppublish
SO  - Amyloid. 2012 Sep;19(3):123-8. doi: 10.3109/13506129.2012.687420. Epub 2012 May 
      25.