PMID- 22626596
OWN - NLM
STAT- MEDLINE
DCOM- 20120810
LR  - 20211021
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Print)
IS  - 1081-1206 (Linking)
VI  - 108
IP  - 6
DP  - 2012 Jun
TI  - Relationships between total and allergen-specific serum IgE concentrations and 
      lung function in young adults.
PG  - 429-34
LID - 10.1016/j.anai.2012.04.008 [doi]
AB  - BACKGROUND: Prior studies have shown relationships between serum immunoglobulin E 
      (IgE) and asthma. OBJECTIVE: To investigate relationships between total and 
      allergen-specific IgE concentrations and lung function in young adults. METHODS: 
      Measurements of total IgE, allergen-specific IgE to 6 common allergens, and 
      spirometry (forced expiratory volume in one second [FEV(1)], forced vital 
      capacity [FVC], FEV(1)/FVC, and percent change in FEV(1) after bronchodilation) 
      were used to calculate correlations between the logarithmically transformed IgE 
      values and measures of lung function among participants in a birth cohort not 
      selected for risk of allergic disease stratified by current asthma, prior asthma, 
      or no asthma. RESULTS: The 428 participants were 51.6% female, 93% white, and 
      18.4 (standard deviation = 0.6) years old. Forty-eight (11.2%) had current 
      asthma, 55 (12.9%) had a history of asthma, and 325 (75.9%) never had asthma. For 
      males with current asthma, correlations between total IgE and FEV(1)% and FVC% 
      were -0.51 (P = .06) and -0.70 (P = .005), respectively. For females with current 
      asthma, the only significant correlation was between total IgE and the FEV(1)/FVC 
      ratio (-0.55, P = .001). After excluding smokers and individuals without 
      detectable allergen-specific IgE, the negative correlations for both males and 
      females remained statistically significant. The correlations among males or 
      females with prior asthma or no history of asthma were minimal and not 
      statistically significant. The sum of the allergen-specific IgEs showed the same 
      pattern of relationships to lung function as did total IgE. CONCLUSION: Our 
      results show significant negative correlations that vary by gender between both 
      total and allergen-specific IgE and measurements of lung function in young adults 
      with current asthma.
CI  - Copyright (c) 2012 American College of Allergy, Asthma & Immunology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Rajendra, Chathruckan
AU  - Rajendra C
AD  - Department of Pediatrics, Georgia Health Sciences University, 1120 15th Street, 
      Augusta, GA 30912, USA.
FAU - Zoratti, Edward
AU  - Zoratti E
FAU - Havstad, Suzanne
AU  - Havstad S
FAU - Nicholas, Charlotte
AU  - Nicholas C
FAU - Wegienka, Ganesa
AU  - Wegienka G
FAU - Cross, M Todd
AU  - Cross MT
FAU - Johnson, Christine C
AU  - Johnson CC
FAU - Ownby, Dennis
AU  - Ownby D
LA  - eng
GR  - P01 AI089473/AI/NIAID NIH HHS/United States
GR  - R01 AI051598/AI/NIAID NIH HHS/United States
GR  - R01 AI059415/AI/NIAID NIH HHS/United States
GR  - R01 AI59415/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/immunology
MH  - Asthma/blood/immunology/*physiopathology
MH  - Cohort Studies
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Immunoglobulin E/*blood/immunology
MH  - Lung/immunology/*physiopathology
MH  - Male
MH  - Sex Factors
MH  - Spirometry
MH  - United States
MH  - Vital Capacity
MH  - Young Adult
PMC - PMC3956048
MID - NIHMS530315
COIS- None of the authors have any real or potential conflicts of interest with any of 
      the information presented in the manuscript.
EDAT- 2012/05/26 06:00
MHDA- 2012/08/11 06:00
PMCR- 2014/03/17
CRDT- 2012/05/26 06:00
PHST- 2012/02/14 00:00 [received]
PHST- 2012/04/10 00:00 [revised]
PHST- 2012/04/10 00:00 [accepted]
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/08/11 06:00 [medline]
PHST- 2014/03/17 00:00 [pmc-release]
AID - S1081-1206(12)00266-9 [pii]
AID - 10.1016/j.anai.2012.04.008 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2012 Jun;108(6):429-34. doi: 
      10.1016/j.anai.2012.04.008.