PMID- 22626966
OWN - NLM
STAT- MEDLINE
DCOM- 20121108
LR  - 20120709
IS  - 1873-3700 (Electronic)
IS  - 0031-9422 (Linking)
VI  - 80
DP  - 2012 Aug
TI  - Secondary metabolites from the root of Ehretia longiflora and their biological 
      activities.
PG  - 50-7
LID - 10.1016/j.phytochem.2012.04.013 [doi]
AB  - Bioassay-guided fractionation of the methanolic extract of the root of Ehretia 
      longiflora (Boraginaceae) afforded eight compounds, ehretiquinone (1), 
      ehretiolide (2), ehreticoumarin (3), ehretilactone A (4), ehretilactone B (5), 
      ehretiamide (6), ehretine (7), and ehretiate (8), together with 12 known 
      compounds (9-20). The relative configuration of 1 was determined by single 
      crystal X-ray diffraction. Among the isolates, 1 and prenylhydroquinone (14) 
      showed antitubercular activity against Mycobacterium tuberculosis strain H37Rv 
      with MIC values of 25.0 and 26.2 mug/mL, respectively. Moreover, 1 exhibited 
      inhibitory effects on N-formylmethionylleucylphenylalanine (fMLP)-induced 
      superoxide production, with IC(5)(0) value of 0.36+/-0.03muM.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Chien, Yu-Chieh
AU  - Chien YC
AD  - Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical 
      University, Kaohsiung 807, Taiwan, ROC.
FAU - Lin, Chu-Hung
AU  - Lin CH
FAU - Chiang, Michael Y
AU  - Chiang MY
FAU - Chang, Hsun-Shuo
AU  - Chang HS
FAU - Liao, Chang-Hui
AU  - Liao CH
FAU - Chen, Ih-Sheng
AU  - Chen IS
FAU - Peng, Chien-Fang
AU  - Peng CF
FAU - Tsai, Ian-Lih
AU  - Tsai IL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120522
PL  - England
TA  - Phytochemistry
JT  - Phytochemistry
JID - 0151434
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antitubercular Agents)
RN  - 0 (Plant Extracts)
RN  - 11062-77-4 (Superoxides)
SB  - IM
MH  - Anti-Inflammatory Agents/isolation & purification/metabolism/pharmacology
MH  - Antitubercular Agents/isolation & purification/metabolism/pharmacology
MH  - Boraginaceae/*metabolism
MH  - Humans
MH  - Inhibitory Concentration 50
MH  - Mycobacterium tuberculosis/drug effects
MH  - Plant Extracts/*isolation & purification/metabolism/*pharmacology
MH  - Plant Roots/*metabolism
MH  - Superoxides/metabolism
EDAT- 2012/05/26 06:00
MHDA- 2012/11/09 06:00
CRDT- 2012/05/26 06:00
PHST- 2011/08/30 00:00 [received]
PHST- 2012/02/29 00:00 [revised]
PHST- 2012/04/24 00:00 [accepted]
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/11/09 06:00 [medline]
AID - S0031-9422(12)00192-6 [pii]
AID - 10.1016/j.phytochem.2012.04.013 [doi]
PST - ppublish
SO  - Phytochemistry. 2012 Aug;80:50-7. doi: 10.1016/j.phytochem.2012.04.013. Epub 2012 
      May 22.