PMID- 22627369
OWN - NLM
STAT- MEDLINE
DCOM- 20120724
LR  - 20151119
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 158 Suppl 1
DP  - 2012
TI  - Inhibition of allergen-induced airway inflammation by low-dose oral immunotherapy 
      with transgenic rice seeds independently of immunoglobulin e synthesis.
PG  - 66-9
LID - 10.1159/000337771 [doi]
AB  - BACKGROUND: Oral immunotherapy is potentially useful for the treatment of 
      allergic diseases. We previously demonstrated that allergen-induced airway 
      inflammation and immunoglobulin E (IgE) production in mice were suppressed by 
      oral administration of high-dose transgenic (Tg) rice seeds (approximately 50 
      g/kg/day) expressing a T cell epitope of Dermatophagoides pteronyssinus group 1 
      allergen (Der p 1). However, this amount of Tg rice seeds was not realistic in 
      our daily life. In this study, allergen-induced airway inflammation and IgE 
      production following oral immunotherapy with a realistic (lowest) dose of Tg rice 
      seeds were investigated. METHODS: Mice orally administered with Tg or non-Tg rice 
      seeds at approximately 5 g/kg/day for 1 week were immunized with recombinant Der 
      p 1, and then challenged with the corresponding allergen. The infiltration of 
      inflammatory cells into the airways and the levels of allergen-specific serum IgE 
      were examined. RESULTS: Low-dose oral administration of Tg rice seeds 
      significantly inhibited the allergen-induced infiltration of eosinophils and 
      lymphocytes into the airways, but allergen-specific IgE synthesis was not 
      changed. CONCLUSIONS: Low-dose oral immunotherapy with Tg rice seeds could 
      suppress allergen-induced airway inflammation through mechanisms other than the 
      downregulation of IgE synthesis.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Saeki, Mayumi
AU  - Saeki M
AD  - Department of Allergy and Immunology, Tokyo Metropolitan Institute of Medical 
      Science, Tokyo, Japan.
FAU - Nishimura, Tomoe
AU  - Nishimura T
FAU - Kaminuma, Osamu
AU  - Kaminuma O
FAU - Suzuki, Kazuya
AU  - Suzuki K
FAU - Takai, Toshiro
AU  - Takai T
FAU - Mori, Akio
AU  - Mori A
FAU - Takada, Kazuko
AU  - Takada K
FAU - Takaiwa, Fumio
AU  - Takaiwa F
FAU - Hiroi, Takachika
AU  - Hiroi T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120515
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Allergens)
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Arthropod Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.4.22.- (Cysteine Endopeptidases)
RN  - EC 3.4.22.- (Dermatophagoides pteronyssinus antigen p 1)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Antigens, Dermatophagoides/immunology
MH  - Arthropod Proteins/immunology
MH  - Cysteine Endopeptidases/immunology
MH  - *Desensitization, Immunologic
MH  - Female
MH  - Immunoglobulin E/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Oryza/*immunology
MH  - Plants, Genetically Modified/*immunology
MH  - Pneumonia/immunology/*therapy
MH  - Seeds/*immunology
EDAT- 2012/06/01 06:00
MHDA- 2012/07/25 06:00
CRDT- 2012/05/26 06:00
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/06/01 06:00 [pubmed]
PHST- 2012/07/25 06:00 [medline]
AID - 000337771 [pii]
AID - 10.1159/000337771 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2012;158 Suppl 1:66-9. doi: 10.1159/000337771. Epub 
      2012 May 15.