PMID- 22627707
OWN - NLM
STAT- MEDLINE
DCOM- 20121029
LR  - 20231214
IS  - 1880-6562 (Electronic)
IS  - 1880-6546 (Print)
IS  - 1880-6546 (Linking)
VI  - 62
IP  - 4
DP  - 2012 Jul
TI  - Acupuncture stimulation at HT7 alleviates depression-induced behavioral changes 
      via regulation of the serotonin system in the prefrontal cortex of 
      maternally-separated rat pups.
PG  - 351-7
LID - 10.1007/s12576-012-0211-1 [doi]
AB  - A possible application of acupuncture in alleviating depression-like behavioral 
      changes and regulating serotonin signaling in the prefrontal cortex (PFC) of 
      maternally-separated rat pups was investigated in this study. On postnatal day 
      15, rat pups were maternally-separated and received acupuncture stimulation at 
      acupoint HT7 or ST36 once a day for 7 days. On postnatal day 21, the tail 
      suspension test was performed and the PFC was harvested. Tissue levels of 
      serotonin (5-HT) and 5-hydroxyindole-3-acetic acid (5-HIAA) were then measured by 
      high-performance liquid chromatography and expression of serotonin transporter 
      (5-HTT) and brain-derived neurotrophic factor (BDNF) were assessed by western 
      blotting. Levels of 5-HT and 5-HIAA were not significantly changed, but the 
      5-HIAA/5-HT ratio was significantly increased by maternal separation. The 
      immobility time of maternally-separated rat pups was increased, and increased 
      5-HTT expression and reduced BDNF level were observed in the PFC. But acupuncture 
      stimulation at HT7 alleviated the behavioral change and regulated the changes of 
      5-HIAA/5-HT ratio, 5-HTT, and BDNF. In conclusion, acupuncture stimulation at HT7 
      can relieve maternal separation-induced changes, and we propose that regulation 
      of the 5-HIAA/5-HT ratio and of 5-HTT expression by acupuncture stimulation are 
      important acupuncture-induced benefits in this animal model of depression.
FAU - Park, Hyemee
AU  - Park H
AD  - Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan 
      National University, Mulgeum-eup, Yangsan, Gyeongsangnam-do 626-870, Republic of 
      Korea.
FAU - Yoo, Doyoung
AU  - Yoo D
FAU - Kwon, Sunoh
AU  - Kwon S
FAU - Yoo, Tae-Won
AU  - Yoo TW
FAU - Park, Hi-Joon
AU  - Park HJ
FAU - Hahm, Dae-Hyun
AU  - Hahm DH
FAU - Lee, Hyejung
AU  - Lee H
FAU - Kim, Seung-Tae
AU  - Kim ST
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120525
PL  - Japan
TA  - J Physiol Sci
JT  - The journal of physiological sciences : JPS
JID - 101262417
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 333DO1RDJY (Serotonin)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
SB  - IM
MH  - Acupuncture Points
MH  - *Acupuncture Therapy
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Depression/*physiopathology
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - *Maternal Deprivation
MH  - Models, Animal
MH  - Motor Activity/physiology
MH  - Prefrontal Cortex/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*metabolism
MH  - Serotonin Plasma Membrane Transport Proteins/metabolism
PMC - PMC10717640
EDAT- 2012/05/26 06:00
MHDA- 2012/10/30 06:00
PMCR- 2012/05/25
CRDT- 2012/05/26 06:00
PHST- 2012/01/11 00:00 [received]
PHST- 2012/05/06 00:00 [accepted]
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/10/30 06:00 [medline]
PHST- 2012/05/25 00:00 [pmc-release]
AID - 211 [pii]
AID - 10.1007/s12576-012-0211-1 [doi]
PST - ppublish
SO  - J Physiol Sci. 2012 Jul;62(4):351-7. doi: 10.1007/s12576-012-0211-1. Epub 2012 
      May 25.