PMID- 22629255
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 3
DP  - 2012
TI  - Therapeutic potential of semi-mature dendritic cells for tolerance induction.
PG  - 123
LID - 10.3389/fimmu.2012.00123 [doi]
LID - 123
AB  - Dendritic cells (DCs) are major players in the control of adaptive tolerance and 
      immunity. Therefore, their specific generation and adoptive transfer into 
      patients or their in vivo targeting is attractive for clinical applications. 
      While injections of mature immunogenic DCs are tested in clinical trials, 
      tolerogenic DCs still are awaiting this step. Besides the tolerogenic potential 
      of immature DCs, also semi-mature DCs can show tolerogenic activity but both 
      types also bear unfavorable features. Optimal tolerogenic DCs, their molecular 
      tool bar, and their use for specific diseases still have to be defined. Here, the 
      usefulness of in vitro generated and adoptively transferred semi-mature DCs for 
      tolerance induction is outlined. The in vivo targeting of semi-mature DCs as 
      represented by steady state migratory DCs are discussed for treatment of 
      autoimmune diseases and allergies. First clinical trials with transcutaneous 
      allergen application may point to their therapeutic use in the future.
FAU - Lutz, Manfred B
AU  - Lutz MB
AD  - Institute of Virology and Immunobiology, University of Wuerzburg Wuerzburg, 
      Germany.
LA  - eng
PT  - Journal Article
DEP - 20120518
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC3355325
OTO - NOTNLM
OT  - dendritic cells
OT  - epicutaneous
OT  - migration
OT  - steady state
OT  - tolerance
OT  - transcutaneous
EDAT- 2012/05/26 06:00
MHDA- 2012/05/26 06:01
PMCR- 2012/01/01
CRDT- 2012/05/26 06:00
PHST- 2012/03/20 00:00 [received]
PHST- 2012/04/30 00:00 [accepted]
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/05/26 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2012.00123 [doi]
PST - epublish
SO  - Front Immunol. 2012 May 18;3:123. doi: 10.3389/fimmu.2012.00123. eCollection 
      2012.