PMID- 22629435
OWN - NLM
STAT- MEDLINE
DCOM- 20121217
LR  - 20220409
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 5
DP  - 2012
TI  - Macular thickness by age and gender in healthy eyes using spectral domain optical 
      coherence tomography.
PG  - e37638
LID - 10.1371/journal.pone.0037638 [doi]
LID - e37638
AB  - PURPOSE: To determine normal macular thickness and its variation by age and 
      gender in healthy eyes using spectral-domain optical coherence tomography 
      (SD-OCT). METHODS: In this cross-sectional analysis, two hundred and twenty eyes 
      of 220 healthy subjects underwent raster scanning using Topcon SD-OCT system, at 
      the Department of Ophthalmology, Dow University of Health Sciences and Civil 
      Hospital Karachi, Pakistan. Macular thickness from all 9 regions of the ETDRS map 
      was documented for each subject. Variations in macular thickness measurements by 
      age and gender were determined. RESULTS: The 220 subjects had a mean age of 45.3 
      years (16-80 years). Using the ETDRS map, foveal thickness for all subjects was 
      measured to be 229+/-20.46 microm. Mean macular thickness for all subjects was 
      262.8+/-13.34 microm. Male gender was associated with greater foveal (p<0.0001) and 
      mean macular (p<0.0001) thickness compared to females. There was no association 
      of mean macular thickness (r(2) = 0.01; p>0.05) and foveal thickness 
      (r(2) = 0.00004; p>0.05) with age. CONCLUSION: We have provided normative data 
      for macular thickness using Topcon SD-OCT system. Our results are comparable to 
      some and vary from other reports using the similar OCT system. Our results 
      suggest that male gender is associated with greater macular thickness, while 
      macular thickness has no association with age in healthy eyes. This is the first 
      normative data for macular thickness from Pakistan; benchmark for diagnosing and 
      monitoring macular pathologies. The values obtained in this study may be useful 
      for comparison with other populations, other SD-OCT systems and future imaging 
      technologies.
FAU - Adhi, Mehreen
AU  - Adhi M
AD  - Department of Ophthalmology, Dow University of Health Sciences and Civil 
      Hospital, Karachi, Pakistan.
FAU - Aziz, Sumbul
AU  - Aziz S
FAU - Muhammad, Kashif
AU  - Muhammad K
FAU - Adhi, Mohammad I
AU  - Adhi MI
LA  - eng
PT  - Journal Article
DEP - 20120521
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fovea Centralis/anatomy & histology
MH  - Humans
MH  - Macula Lutea/*anatomy & histology
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - Sex Factors
MH  - Tomography, Optical Coherence
PMC - PMC3357395
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2012/05/26 06:00
MHDA- 2012/12/18 06:00
PMCR- 2012/05/21
CRDT- 2012/05/26 06:00
PHST- 2012/02/21 00:00 [received]
PHST- 2012/04/26 00:00 [accepted]
PHST- 2012/05/26 06:00 [entrez]
PHST- 2012/05/26 06:00 [pubmed]
PHST- 2012/12/18 06:00 [medline]
PHST- 2012/05/21 00:00 [pmc-release]
AID - PONE-D-12-05174 [pii]
AID - 10.1371/journal.pone.0037638 [doi]
PST - ppublish
SO  - PLoS One. 2012;7(5):e37638. doi: 10.1371/journal.pone.0037638. Epub 2012 May 21.