PMID- 22633012
OWN - NLM
STAT- MEDLINE
DCOM- 20130503
LR  - 20211021
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 199
IP  - 2
DP  - 2012 Sep 30
TI  - Platelet protein kinase C and brain-derived neurotrophic factor levels in 
      borderline personality disorder patients.
PG  - 92-7
LID - S0165-1781(12)00211-9 [pii]
LID - 10.1016/j.psychres.2012.04.026 [doi]
AB  - Borderline personality disorder (BPD) is a prevalent and difficult to treat 
      psychiatric condition characterized by abrupt mood swings, intense anger and 
      depression, unstable interpersonal relationships, impulsive self-destructive 
      behavior and a suicide rate of approximately 10%. Possible underlying molecular 
      dysregulations in BPD have not been well explored. Protein kinase C (PKC) and 
      brain-derived neurotrophic factor (BDNF) have both been implicated in affective 
      disorders, but their role in BPD has not been examined. Platelets were isolated 
      from blood obtained from 24 medication-free BPD patients and 18 healthy control 
      subjects. PKC-alpha, phosphorylated-PKC-alpha (p-PKCalpha), PKC-betaII, and BDNF were measured 
      in platelet homogenates by immunoblotting. In the males, platelet BDNF and PKC-alpha 
      levels were lower in patients than controls. p-PKC-alpha and PKC-betaII were lower at 
      trend levels. In the entire sample, platelet p-PKCalpha and PKC-alpha activity were 
      lower, at a trend level, in patients compared to controls. This is the first 
      report to our knowledge of PKC and BDNF activity in BPD and calls for 
      replication. These findings are consistent with altered PKC and BDNF activity in 
      a range of neuropsychiatric conditions including bipolar disorder, depression and 
      suicide.
CI  - Published by Elsevier Ireland Ltd.
FAU - Koenigsberg, Harold W
AU  - Koenigsberg HW
AD  - Mount Sinai School of Medicine, Department of Psychiatry, New York, NY, USA. 
      HWarrenK@nyc.rr.com
FAU - Yuan, Peixiong
AU  - Yuan P
FAU - Diaz, George A
AU  - Diaz GA
FAU - Guerreri, Stephanie
AU  - Guerreri S
FAU - Dorantes, Christine
AU  - Dorantes C
FAU - Mayson, Sarahjo
AU  - Mayson S
FAU - Zamfirescu, Constantin
AU  - Zamfirescu C
FAU - New, Antonia S
AU  - New AS
FAU - Goodman, Marianne
AU  - Goodman M
FAU - Manji, Husseini K
AU  - Manji HK
FAU - Siever, Larry J
AU  - Siever LJ
LA  - eng
GR  - M01 RR000071/RR/NCRR NIH HHS/United States
GR  - 5MO1RR00071/RR/NCRR NIH HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120526
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Isoenzymes)
RN  - EC 2.7.11.13 (Protein Kinase C)
SB  - IM
MH  - Adult
MH  - Blood Platelets/*chemistry/enzymology
MH  - Blotting, Western
MH  - Borderline Personality Disorder/*blood/enzymology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Isoenzymes/blood
MH  - Male
MH  - Protein Kinase C/*blood
PMC - PMC4128317
MID - NIHMS381067
COIS- CONFLICT OF INTEREST The authors have no financial conflicts of interest with 
      regard to the content of this work.
EDAT- 2012/05/29 06:00
MHDA- 2013/05/04 06:00
PMCR- 2014/08/11
CRDT- 2012/05/29 06:00
PHST- 2011/06/21 00:00 [received]
PHST- 2012/04/16 00:00 [revised]
PHST- 2012/04/18 00:00 [accepted]
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2013/05/04 06:00 [medline]
PHST- 2014/08/11 00:00 [pmc-release]
AID - S0165-1781(12)00211-9 [pii]
AID - 10.1016/j.psychres.2012.04.026 [doi]
PST - ppublish
SO  - Psychiatry Res. 2012 Sep 30;199(2):92-7. doi: 10.1016/j.psychres.2012.04.026. 
      Epub 2012 May 26.