PMID- 22633192
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20120706
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 249
IP  - 1-2
DP  - 2012 Aug 15
TI  - BDNF -270 C>T polymorphisms might be associated with stroke type and BDNF -196 
      G>A corresponds to early neurological deficit in hemorrhagic stroke.
PG  - 71-5
LID - 10.1016/j.jneuroim.2012.04.011 [doi]
AB  - Genetic factors might be involved in stroke prognosis, however the role of 
      brain-derived neurotrophic factor (BDNF) in stroke recovery is unknown. We have 
      studied BDNF -196 G>A and -270 C>T polymorphisms in ischemic and hemorrhagic 
      stroke and their impact on stroke prognosis. There was higher occurrence of BDNF 
      -270 CC genotype in patients with hemorrhagic than ischemic stroke (96% versus 
      86%, p=0.0495). In hemorrhagic stroke BDNF -196 GG carriers scored better in 
      NIHSS at admission (14.23 versus 21.00, p=0.0192) and after 7days (8.60 versus 
      15.00, p=0.0408) of onsets. None of the determined polymorphisms had any impact 
      on 30-day early outcome in ischemic and hemorrhagic stroke.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Mirowska-Guzel, Dagmara
AU  - Mirowska-Guzel D
AD  - Department of Experimental and Clinical Pharmacology, Medical University of 
      Warsaw, Warsaw, Poland.
FAU - Gromadzka, Grazyna
AU  - Gromadzka G
FAU - Czlonkowski, Andrzej
AU  - Czlonkowski A
FAU - Czlonkowska, Anna
AU  - Czlonkowska A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120524
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Brain Ischemia/complications/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Humans
MH  - Intracranial Hemorrhages/complications/*genetics
MH  - Male
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Restriction Fragment Length
MH  - Prognosis
MH  - Recovery of Function/*genetics
MH  - Stroke/etiology/*genetics
EDAT- 2012/05/29 06:00
MHDA- 2012/09/11 06:00
CRDT- 2012/05/29 06:00
PHST- 2012/01/09 00:00 [received]
PHST- 2012/04/19 00:00 [revised]
PHST- 2012/04/22 00:00 [accepted]
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
AID - S0165-5728(12)00128-2 [pii]
AID - 10.1016/j.jneuroim.2012.04.011 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2012 Aug 15;249(1-2):71-5. doi: 10.1016/j.jneuroim.2012.04.011. 
      Epub 2012 May 24.