PMID- 22633285
OWN - NLM
STAT- MEDLINE
DCOM- 20121016
LR  - 20121130
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 59
IP  - 2
DP  - 2012 Aug
TI  - Association of IL-4 receptor gene polymorphisms with high density lipoprotein 
      cholesterol.
PG  - 309-12
LID - 10.1016/j.cyto.2012.04.023 [doi]
AB  - The aim of this study is to investigate the correlation between E400A 
      polymorphisms of interleukin-4 receptor alpha chain (IL-4Ralpha) and lipid metabolism. 
      Genomic DNA from 121 type 2 diabetes mellitus (T2DM) patients and 113 
      non-diabetic, non-obese control study subjects were extracted, and their IL-4Ralpha 
      E400A polymorphisms were analyzed by PCR-RFLP. The correlation between IL-4Ralpha 
      E400A genotypes and study subjects' lipid profile was then examined. Significant 
      associations of the IL-4Ralpha E400A genotypes and high density 
      lipoprotein-cholesterol (HDL-C) levels among control individuals (p=0.007), as 
      well as among the T2DM patients (p=0.029), were observed. Significant 
      correlations between IL-4Ralpha E400A genotypes with blood pressure, as well as with 
      blood urea nitrogen, were also observed in control subjects. Our results reveal 
      that IL-4Ralpha may play certain roles in the lipid metabolism of Taiwanese 
      population and suggest a novel link between lipid metabolism and the cytokine 
      receptor.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Chang, Yih-Hsin
AU  - Chang YH
AD  - Department of Biotechnology and Laboratory Science in Medicine, National 
      Yang-Ming University, Taipei 112, Taiwan.
FAU - Huang, Chien-Ning
AU  - Huang CN
FAU - Shiau, Ming-Yuh
AU  - Shiau MY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120524
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Cholesterol, HDL)
RN  - 0 (IL4R protein, human)
RN  - 0 (Interleukin-4 Receptor alpha Subunit)
SB  - IM
MH  - Case-Control Studies
MH  - Cholesterol, HDL/*blood
MH  - Demography
MH  - Diabetes Mellitus, Type 2/blood/genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Interleukin-4 Receptor alpha Subunit/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
EDAT- 2012/05/29 06:00
MHDA- 2012/10/17 06:00
CRDT- 2012/05/29 06:00
PHST- 2011/07/27 00:00 [received]
PHST- 2012/03/28 00:00 [revised]
PHST- 2012/04/18 00:00 [accepted]
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2012/10/17 06:00 [medline]
AID - S1043-4666(12)00153-6 [pii]
AID - 10.1016/j.cyto.2012.04.023 [doi]
PST - ppublish
SO  - Cytokine. 2012 Aug;59(2):309-12. doi: 10.1016/j.cyto.2012.04.023. Epub 2012 May 
      24.