PMID- 22633920
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20220408
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 233
IP  - 2
DP  - 2012 Aug 1
TI  - Maternal high-fat diet in mice programs emotional behavior in adulthood.
PG  - 398-404
LID - 10.1016/j.bbr.2012.05.027 [doi]
AB  - The maternal environment has a significant role in the normal development of the 
      fetus and may have long-term impact on brain development including critical 
      central pathways such as the gamma-aminobutyric acid (GABA), serotonergic and the 
      neurotrophin systems. For example, maternal malnutrition plays an important role 
      in programming many aspects of physiology and behavior including predisposition 
      to mental-health related disorders such as anxiety. Here we investigated the 
      effects of maternal high-fat diet or control diet for nine weeks (prior to 
      gestation, gestation and lactation) on the adult offspring with respect to 
      anxiety related behaviors as well as exploration and conditioned fear response. 
      We found that offspring born to high-fat diet mothers showed increased 
      anxiety-like behaviors, but intact conditioned fear response and exploratory 
      behavior. In addition, brain-derived neurotrophic factor (BDNF) was significantly 
      increased in the dorsal hippocampus, while GABA(A) alpha2 receptor subunit and 
      5-hydroxytryptamine 1A (5-HT1A) receptor showed increased levels in the ventral 
      hippocampus. In summary, these findings suggest that maternal high-fat diet 
      consumption during critical periods in the development of the fetus, might 
      increase the risk of abnormal behaviors in adulthood related to anxiety.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Peleg-Raibstein, Daria
AU  - Peleg-Raibstein D
AD  - The Swiss Federal Institute of Technology, ETH Zurich, Institute of Food 
      Nutrition and Health, Schorenstrasse 16, 8603 Schwerzenbach, Switzerland. 
      daria-peleg@ethz.ch
FAU - Luca, Edlira
AU  - Luca E
FAU - Wolfrum, Christian
AU  - Wolfrum C
LA  - eng
PT  - Journal Article
DEP - 20120523
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Conditioning, Classical/drug effects/physiology
MH  - Diet, High-Fat/*adverse effects
MH  - Emotions/*drug effects
MH  - Exploratory Behavior/physiology
MH  - Female
MH  - Male
MH  - Maze Learning/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mood Disorders/*etiology/pathology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically induced/*physiopathology
MH  - Transition Temperature
EDAT- 2012/05/29 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/05/29 06:00
PHST- 2012/04/17 00:00 [received]
PHST- 2012/05/08 00:00 [revised]
PHST- 2012/05/14 00:00 [accepted]
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - S0166-4328(12)00365-8 [pii]
AID - 10.1016/j.bbr.2012.05.027 [doi]
PST - ppublish
SO  - Behav Brain Res. 2012 Aug 1;233(2):398-404. doi: 10.1016/j.bbr.2012.05.027. Epub 
      2012 May 23.