PMID- 22634506
OWN - NLM
STAT- MEDLINE
DCOM- 20121116
LR  - 20211021
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 218
DP  - 2012 Aug 30
TI  - Variable prenatal stress results in impairments of sustained attention and 
      inhibitory response control in a 5-choice serial reaction time task in rats.
PG  - 126-37
LID - 10.1016/j.neuroscience.2012.05.040 [doi]
AB  - Rats repeatedly exposed to variable prenatal stress (PNS) exhibit 
      schizophrenia-like behavioral signs such as social withdrawal, elevations in 
      amphetamine-induced locomotor activity, deficits in sensory-motor gating, as well 
      as impairments in memory-related task performance. However, to date there have 
      been no studies designed to test the hypothesis that variable PNS would lead to 
      disruptions in sustained attention and inhibitory response control (i.e., 
      symptoms also commonly observed in schizophrenia and other neuropsychiatric 
      disorders such as attention-deficit hyperactivity disorder). In the current 
      study, the effects of variable PNS in rats were evaluated in fixed and variable 
      stimulus duration (VSD) as well as variable intertrial interval (VITI) versions 
      of a 5-choice serial reaction time task (5C-SRTT). In a separate series of 
      experiments, the glutamate (N-methyl-d-aspartate [NMDA]) antagonist, MK-801 
      (0.025-0.05 mg/kg), and the norepinephrine reuptake inhibitor, atomoxetine 
      (0.30-3.0mg/kg), were administered acutely to assess the sensitivity of PNS 
      subjects to glutamatergic and noradrenergic manipulations. The results indicated 
      that exposure to variable PNS significantly impaired accuracy in the VSD version 
      of the 5C-SRTT and increased premature and timeout responses in the VITI version. 
      In addition, both doses of MK-801 impaired accuracy, increased premature and 
      timeout responses in PNS, but not control subjects. In contrast, atomoxetine 
      decreased premature and timeout responses in both PNS and control subjects in the 
      VITI version of the task and improved accuracy in the PNS subjects. The results 
      suggest that exposure to variable PNS in rats results in impairments of sustained 
      attention and inhibitory response control and that these deficits can be 
      exacerbated by NMDA antagonism and improved by a norepinephrine uptake inhibitor. 
      Collectively, these data further support the premise that variable PNS in rats is 
      a valid model system for the study of neuropsychiatric disorders and their 
      treatment.
CI  - Copyright (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Wilson, C A
AU  - Wilson CA
AD  - Department of Pharmacology and Toxicology, Georgia Health Sciences University, 
      Augusta, GA 30912, United States.
FAU - Schade, R
AU  - Schade R
FAU - Terry, A V Jr
AU  - Terry AV Jr
LA  - eng
GR  - ES012241/ES/NIEHS NIH HHS/United States
GR  - DA029127/DA/NIDA NIH HHS/United States
GR  - R01 DA029127/DA/NIDA NIH HHS/United States
GR  - R01 AG029617/AG/NIA NIH HHS/United States
GR  - AG029617/AG/NIA NIH HHS/United States
GR  - R01 ES012241/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120523
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
SB  - IM
MH  - Animals
MH  - Attention/*physiology
MH  - Disease Models, Animal
MH  - Female
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects/physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reaction Time/*physiology
MH  - Schizophrenia/physiopathology
MH  - Stress, Psychological/*complications
PMC - PMC3515673
MID - NIHMS380396
EDAT- 2012/05/29 06:00
MHDA- 2012/12/10 06:00
PMCR- 2013/08/30
CRDT- 2012/05/29 06:00
PHST- 2012/04/03 00:00 [received]
PHST- 2012/05/09 00:00 [revised]
PHST- 2012/05/15 00:00 [accepted]
PHST- 2012/05/29 06:00 [entrez]
PHST- 2012/05/29 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PHST- 2013/08/30 00:00 [pmc-release]
AID - S0306-4522(12)00508-8 [pii]
AID - 10.1016/j.neuroscience.2012.05.040 [doi]
PST - ppublish
SO  - Neuroscience. 2012 Aug 30;218:126-37. doi: 10.1016/j.neuroscience.2012.05.040. 
      Epub 2012 May 23.