PMID- 2263960
OWN - NLM
STAT- MEDLINE
DCOM- 19910205
LR  - 20131121
IS  - 0371-0874 (Print)
IS  - 0371-0874 (Linking)
VI  - 42
IP  - 4
DP  - 1990 Aug
TI  - [Effect of the overactivated central renin-angiotensin system on the 
      concentration of brain norepinephrine and epinephrine in stroke-prone 
      spontaneously hypertensive rats and its significances].
PG  - 379-84
AB  - The content of norepinephrine (NE) and epinephrine (E) in the brain of 
      spontaneously hypertensive rats has proved abnormal, but the cause remained 
      unknown. It was shown in the recent work that NE content in pons, posterior 
      hypothalamus, nucleus caudatus and E concentration in medulla oblongata, anterior 
      and posterior hypothalamus of 12-week old stroke-prone spontaneously hypertensive 
      rats (SHRSP) were much higher than those of age-matched Wister-Kyoto rats (WKY). 
      SHRSP also showed higher levels of systolic blood pressure (SBP) and brain 
      angiotensin II (A II) than WKY. Intracerebroventricular (icv) perfusion of 
      angiotensin-converting enzyme inhibitor captopril (20 micrograms for each time 
      and three times for each day for four weeks) inhibited the synthesis of brain A 
      II and reduced SBP and NE, E contents in all examined brain areas in SHRSP and 
      WKY. However, the effects of chronically perfused captopril on SBP and brain NE, 
      E levels in SHRSP were much more significant than in WKY. The results indicate 
      that the modulatory effects of central renin-angiotensin system (RAS) on central 
      adrenergic and noradrenergic system might be overactivated in SHRSP, which might 
      partially responsible for the abnormally high levels of NE, E in some of the 
      brain areas of SHRSP.
FAU - Ding, H
AU  - Ding H
AD  - Department of Physiology, Tongji Medical University, Wuhan, Hubei.
FAU - Zhou, Q
AU  - Zhou Q
FAU - Deng, J
AU  - Deng J
FAU - Lo, H Y
AU  - Lo HY
FAU - Yang, K
AU  - Yang K
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sheng Li Xue Bao
JT  - Sheng li xue bao : [Acta physiologica Sinica]
JID - 20730130R
RN  - 11128-99-7 (Angiotensin II)
RN  - 9G64RSX1XD (Captopril)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Angiotensin II/metabolism
MH  - Animals
MH  - Brain/*metabolism
MH  - Captopril/pharmacology
MH  - Epinephrine/*metabolism
MH  - Hypertension/*metabolism
MH  - Male
MH  - Norepinephrine/*metabolism
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Renin-Angiotensin System/*physiology
EDAT- 1990/08/01 00:00
MHDA- 1990/08/01 00:01
CRDT- 1990/08/01 00:00
PHST- 1990/08/01 00:00 [pubmed]
PHST- 1990/08/01 00:01 [medline]
PHST- 1990/08/01 00:00 [entrez]
PST - ppublish
SO  - Sheng Li Xue Bao. 1990 Aug;42(4):379-84.