PMID- 22640916
OWN - NLM
STAT- MEDLINE
DCOM- 20130618
LR  - 20151119
IS  - 0172-6390 (Print)
IS  - 0172-6390 (Linking)
VI  - 59
IP  - 119
DP  - 2012 Oct
TI  - Using a small-for-size graft might attribute to the future use of left-lobe 
      living graft in adult to adult living donor liver transplantation.
PG  - 2050-3
AB  - BACKGROUND/AIMS: Adult to adult living donor liver transplantation (AALDLT) is 
      performed worldwide. The aim of this study was to evaluate using a graft with 
      graft to body weight ratio (GBWR) less than 0.8 in right-lobe AALDLT recipients. 
      METHODOLOGY: Clinical data of 127 patients who had right-lobe AALDLT from January 
      2002 to November 2009 were retrospectively analyzed. Patients were divided into 
      two groups according to GBWR (group A: 0.6 </= GBWR < 0.8, group B: GBWR >/= 0.8). 
      Preoperative characteristics, postoperative complications graded by the Clavien 
      score and patient survival time were recorded and analyzed. RESULTS: GBWR between 
      the two groups were significantly different (0.67 +/- 0.05 vs. 0.97 +/- 0.17, p = 
      0.000). There was no significant difference in preoperative demographic data as 
      well as postoperative liver function data. Complication rate, median ICU stay and 
      small-for-size syndrome incidence were similar in both groups. In univariate 
      analysis, only MELD emerged as independent risk factor for small-for-size 
      syndrome (p = 0.045). Patient survival was similar in both groups at 1, 3 and 5 
      years as well. CONCLUSIONS: Using a GBWR of less than 0.8 is safe in selected 
      recipients. To some extent, this result may attribute to the wide use of 
      left-lobe living graft in AALDLT in future.
FAU - Li, Hong-Yu
AU  - Li HY
AD  - Department of Liver and Vascular Surgery, Center of Liver Transplantation, West 
      China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
FAU - Wei, Yong-Gang
AU  - Wei YG
FAU - Yan, Lv-Nan
AU  - Yan LN
FAU - Wen, Tian-Fu
AU  - Wen TF
FAU - Zhao, Ji-Chun
AU  - Zhao JC
FAU - Xu, Ming-Qing
AU  - Xu MQ
FAU - Wang, Wen-Tao
AU  - Wang WT
FAU - Yang, Jia-Yin
AU  - Yang JY
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Hepatogastroenterology
JT  - Hepato-gastroenterology
JID - 8007849
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Chi-Square Distribution
MH  - *Donor Selection
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Intensive Care Units
MH  - Kaplan-Meier Estimate
MH  - Length of Stay
MH  - *Liver Transplantation/adverse effects/mortality
MH  - *Living Donors
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/blood/mortality/therapy
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Time Factors
MH  - Tissue Donors/*supply & distribution
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2012/05/30 06:00
MHDA- 2013/06/19 06:00
CRDT- 2012/05/30 06:00
PHST- 2012/05/30 06:00 [entrez]
PHST- 2012/05/30 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - 10.5754/hge12261 [doi]
PST - ppublish
SO  - Hepatogastroenterology. 2012 Oct;59(119):2050-3. doi: 10.5754/hge12261.