PMID- 22640929
OWN - NLM
STAT- MEDLINE
DCOM- 20140131
LR  - 20220318
IS  - 1873-3700 (Electronic)
IS  - 0031-9422 (Linking)
VI  - 91
DP  - 2013 Jul
TI  - Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker 
      fa/fa rats.
PG  - 236-41
LID - S0031-9422(12)00200-2 [pii]
LID - 10.1016/j.phytochem.2012.04.018 [doi]
AB  - Obesity contributes to increased risk for several chronic diseases including 
      cardiovascular disease and type 2 diabetes. Xanthohumol, a prenylated flavonoid 
      from hops (Humulus lupulus), was tested for efficacy on biomarkers of metabolic 
      syndrome in 4 week old Zucker fa/fa rats, a rodent model of obesity. Rats 
      received daily oral doses of xanthohumol at 0, 1.86, 5.64, and 16.9 mg/kg BW for 
      6 weeks. All rats were maintained on a high fat (60% kcal) AIN-93G diet for 3 
      weeks to induce severe obesity followed by a normal AIN-93G (15% kcal fat) diet 
      for the last 3 weeks of the study. Weekly food intake and body weight were 
      recorded. Plasma cholesterol, glucose, insulin, triglyceride, and monocyte 
      chemoattractant protein-1 (MCP-1) levels were assessed using commercial assay 
      kits. Plasma and liver tissue levels of XN and its metabolites were determined by 
      liquid-chromatography tandem mass spectrometry. Plasma and liver tissue levels of 
      xanthohumol were similar between low and medium dose groups and significantly 
      (p<0.05) elevated in the highest dose group. There was a dose-dependent effect on 
      body weight and plasma glucose levels. The highest dose group (n=6) had 
      significantly lower plasma glucose levels compared to the control group (n=6) in 
      male but not female rats. There was also a significant decrease in body weight 
      for male rats in the highest dose group (16.9 mg/kg BW) compared to rats that 
      received no xanthohumol, which was also not seen for female rats. Plasma 
      cholesterol, insulin, triglycerides, and MCP-1 as well as food intake were not 
      affected by treatment. The findings suggest that xanthohumol has beneficial 
      effects on markers of metabolic syndrome.
CI  - Copyright (c) 2012. Published by Elsevier Ltd.
FAU - Legette, Leecole L
AU  - Legette LL
AD  - Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.
FAU - Luna, Arlyn Y Moreno
AU  - Luna AY
FAU - Reed, Ralph L
AU  - Reed RL
FAU - Miranda, Cristobal L
AU  - Miranda CL
FAU - Bobe, Gerd
AU  - Bobe G
FAU - Proteau, Rosita R
AU  - Proteau RR
FAU - Stevens, Jan F
AU  - Stevens JF
LA  - eng
GR  - P30 ES000210/ES/NIEHS NIH HHS/United States
GR  - R21AT005294/AT/NCCIH NIH HHS/United States
GR  - S10 RR022589/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120527
PL  - England
TA  - Phytochemistry
JT  - Phytochemistry
JID - 0151434
RN  - 0 (Blood Glucose)
RN  - 0 (Flavonoids)
RN  - 0 (Propiophenones)
RN  - T4467YT1NT (xanthohumol)
SB  - IM
MH  - Animals
MH  - Blood Glucose/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Eating/drug effects
MH  - *Fasting
MH  - Female
MH  - Flavonoids/blood/chemistry/*pharmacology
MH  - Male
MH  - Molecular Structure
MH  - Obesity/*drug therapy
MH  - Propiophenones/blood/chemistry/*pharmacology
MH  - Rats
MH  - Rats, Zucker
MH  - Weight Loss/*drug effects
EDAT- 2012/05/30 06:00
MHDA- 2014/02/01 06:00
CRDT- 2012/05/30 06:00
PHST- 2011/11/08 00:00 [received]
PHST- 2012/04/04 00:00 [revised]
PHST- 2012/04/30 00:00 [accepted]
PHST- 2012/05/30 06:00 [entrez]
PHST- 2012/05/30 06:00 [pubmed]
PHST- 2014/02/01 06:00 [medline]
AID - S0031-9422(12)00200-2 [pii]
AID - 10.1016/j.phytochem.2012.04.018 [doi]
PST - ppublish
SO  - Phytochemistry. 2013 Jul;91:236-41. doi: 10.1016/j.phytochem.2012.04.018. Epub 
      2012 May 27.