PMID- 22641131
OWN - NLM
STAT- MEDLINE
DCOM- 20121120
LR  - 20190911
IS  - 1347-8648 (Electronic)
IS  - 1347-8613 (Linking)
VI  - 119
IP  - 1
DP  - 2012
TI  - Possible modulation of process extension by N-methyl-D-aspartate receptor 
      expressed in osteocytic MLO-Y4 cells.
PG  - 112-6
AB  - In contrast to osteoblasts, little attention has been paid to expression profiles 
      of different glutamatergic signaling machineries in osteocytes, which are the 
      most abundant cells with a possible role as a mechanical sensor in bone. Here, we 
      show that N-methyl-D-aspartate receptor (NMDAR) is expressed by osteocytic cells 
      in five-weeks-old mouse tibiae in vivo as well as by osteocytic MLO-Y4 cells in 
      vitro. Sustained exposure to the NMDAR antagonist dizocilpine significantly 
      increased the number of cells with processes in cultured MLO-Y4 cells. These 
      results suggest that NMDAR would be expressed by osteocytes with an unidentified 
      role in the process extension.
FAU - Fujita, Hiroyuki
AU  - Fujita H
AD  - Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, 
      Kanazawa University Graduate School of Natural Science and Technology, 
      Kakuma-machi, Ishikawa, Japan.
FAU - Hinoi, Eiichi
AU  - Hinoi E
FAU - Nakatani, Eri
AU  - Nakatani E
FAU - Yamamoto, Tomomi
AU  - Yamamoto T
FAU - Takarada, Takeshi
AU  - Takarada T
FAU - Yoneda, Yukio
AU  - Yoneda Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120428
PL  - Japan
TA  - J Pharmacol Sci
JT  - Journal of pharmacological sciences
JID - 101167001
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Animals
MH  - Bone and Bones/metabolism
MH  - Cells, Cultured
MH  - Glutamic Acid/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Osteocytes/*metabolism
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
EDAT- 2012/05/30 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/05/30 06:00
PHST- 2012/05/30 06:00 [entrez]
PHST- 2012/05/30 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - JST.JSTAGE/jphs/12068SC [pii]
AID - 10.1254/jphs.12068sc [doi]
PST - ppublish
SO  - J Pharmacol Sci. 2012;119(1):112-6. doi: 10.1254/jphs.12068sc. Epub 2012 Apr 28.