PMID- 22641568
OWN - NLM
STAT- MEDLINE
DCOM- 20130823
LR  - 20220321
IS  - 1724-6059 (Electronic)
IS  - 1121-8428 (Linking)
VI  - 26
IP  - 1
DP  - 2013 Jan-Feb
TI  - Aldosterone mediates glomerular inflammation in experimental mesangial 
      proliferative glomerulonephritis.
PG  - 199-206
LID - 10.5301/jn.5000125 [doi]
AB  - BACKGROUND: The renoprotection of the mineralocorticoid receptor antagonist (MRA) 
      is considered to be mainly via its antifibrotic activity, and the possibility 
      that it may also have antiinflammatory effects has not been studied. We tested 
      the hypothesis that MRA might influence the inflammatory changes that accompany 
      experimental glomerular injury. METHODS: Administration of vehicle (control) or a 
      selective MRA, eplerenone (50 mg/kg x 2 times/day) was started 7 days (-7d) 
      before induction of anti-Thy-1.1 glomerulonephritis. Kidney samples were 
      evaluated serially over a 12-day period for the presence of cell proliferation, 
      macrophage infiltration, mesangial cell phenotypic activation and expression of 
      the chemokine monocyte chemoattractant protein-1 (MCP-1). RESULTS: MRA did not 
      prevent the mesangiolysis associated with anti-Thy-1 antibody. However, MRA 
      significantly inhibited MCP-1 expression, glomerular macrophage infiltration and 
      mesangial phenotypic activation (alpha-smooth muscle actin expression). 
      CONCLUSION: MRA alters glomerular inflammation and mesangial cell activation in 
      experimental glomerular injury. MRA may be a novel way to treat acute glomerular 
      diseases.
FAU - Qin, Danping
AU  - Qin D
AD  - Division of Nephrology, Department of Medicine, Showa University Fujigaoka 
      Hospital, Yokohama, Japan.
FAU - Morita, Hiroyuki
AU  - Morita H
FAU - Inui, Kiyoko
AU  - Inui K
FAU - Tayama, Hironori
AU  - Tayama H
FAU - Inoue, Yoshihiko
AU  - Inoue Y
FAU - Yoshimura, Ashio
AU  - Yoshimura A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - J Nephrol
JT  - Journal of nephrology
JID - 9012268
RN  - 0 (Actins)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Isoantibodies)
RN  - 0 (Mineralocorticoid Receptor Antagonists)
RN  - 0 (anti-Thy antibody)
RN  - 0 (smooth muscle actin, rat)
RN  - 27O7W4T232 (Spironolactone)
RN  - 4964P6T9RB (Aldosterone)
RN  - 6995V82D0B (Eplerenone)
RN  - 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine)
RN  - AYI8EX34EU (Creatinine)
RN  - G9481N71RO (Deoxyguanosine)
SB  - IM
MH  - 8-Hydroxy-2'-Deoxyguanosine
MH  - Actins/metabolism
MH  - Aldosterone/metabolism
MH  - Animals
MH  - Cell Movement/drug effects
MH  - Cell Proliferation/drug effects
MH  - Chemokine CCL2/*metabolism
MH  - Creatinine/blood
MH  - Deoxyguanosine/analogs & derivatives/urine
MH  - Eplerenone
MH  - Glomerulonephritis, Membranoproliferative/chemically 
      induced/*metabolism/pathology
MH  - Isoantibodies
MH  - Macrophages
MH  - Male
MH  - Mesangial Cells/metabolism
MH  - Mineralocorticoid Receptor Antagonists/*pharmacology
MH  - Proteinuria/urine
MH  - Rats
MH  - Rats, Wistar
MH  - Spironolactone/*analogs & derivatives/pharmacology
EDAT- 2012/05/30 06:00
MHDA- 2013/08/24 06:00
CRDT- 2012/05/30 06:00
PHST- 2012/02/06 00:00 [accepted]
PHST- 2012/05/30 06:00 [entrez]
PHST- 2012/05/30 06:00 [pubmed]
PHST- 2013/08/24 06:00 [medline]
AID - 9A41DC4F-7589-4A6B-B209-37E32162C0DF [pii]
AID - 10.5301/jn.5000125 [doi]
PST - ppublish
SO  - J Nephrol. 2013 Jan-Feb;26(1):199-206. doi: 10.5301/jn.5000125.