PMID- 22641689
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20240210
IS  - 1477-9137 (Electronic)
IS  - 0021-9533 (Linking)
VI  - 125
IP  - Pt 10
DP  - 2012 May 15
TI  - Autophagy and cancer--issues we need to digest.
PG  - 2349-58
LID - 10.1242/jcs.093708 [doi]
AB  - Autophagy is an evolutionarily conserved catabolic pathway that has multiple 
      roles in carcinogenesis and cancer therapy. It can inhibit the initiation of 
      tumorigenesis through limiting cytoplasmic damage, genomic instability and 
      inflammation, and the loss of certain autophagy genes can lead to cancer. 
      Conversely, autophagy can also assist cells in dealing with stressful metabolic 
      environments, thereby promoting cancer cell survival. In fact, some cancers rely 
      on autophagy to survive and progress. Furthermore, tumour cells can exploit 
      autophagy to cope with the cytotoxicity of certain anticancer drugs. By contrast, 
      it appears that certain therapeutics require autophagy for the effective killing 
      of cancer cells. Despite these dichotomies, it is clear that autophagy has an 
      important, if complex, role in cancer. This is further exemplified by the fact 
      that autophagy is connected with major cancer networks, including those driven by 
      p53, mammalian target of rapamycin (mTOR), RAS and glutamine metabolism. In this 
      Commentary, we highlight recent advances in our understanding of the role that 
      autophagy has in cancer and discuss current strategies for targeting autophagy 
      for therapeutic gain.
FAU - Liu, Emma Y
AU  - Liu EY
AD  - Tumour Cell Death Laboratory, Beatson Institute for Cancer Research, Garscube 
      Estate, Glasgow, UK.
FAU - Ryan, Kevin M
AU  - Ryan KM
LA  - eng
GR  - 15816/CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120528
PL  - England
TA  - J Cell Sci
JT  - Journal of cell science
JID - 0052457
SB  - IM
MH  - Animals
MH  - *Autophagy
MH  - Humans
MH  - Neoplasms/metabolism/*physiopathology/therapy
EDAT- 2012/05/30 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/05/30 06:00
PHST- 2012/05/30 06:00 [entrez]
PHST- 2012/05/30 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - jcs.093708 [pii]
AID - 10.1242/jcs.093708 [doi]
PST - ppublish
SO  - J Cell Sci. 2012 May 15;125(Pt 10):2349-58. doi: 10.1242/jcs.093708. Epub 2012 
      May 28.