PMID- 22641976
OWN - NLM
STAT- MEDLINE
DCOM- 20120723
LR  - 20191112
IS  - 0001-5385 (Print)
IS  - 0001-5385 (Linking)
VI  - 67
IP  - 2
DP  - 2012 Apr
TI  - In patients with hypertrophic cardiomyopathy myocardial fibrosis is associated 
      with both left ventricular and left atrial dysfunction.
PG  - 187-93
AB  - AIMS: The aim of this study was to assess LA function by two-dimensional 
      speckle-tracking echocardiography and its relation with myocardial fibrosis in 
      hypertrophic cardiomyopathy (HCM). METHODS: We enrolled 30 consecutive 
      HCM-patients in our study (20 males; age: 49.7 +/- 10.4 years, NYHA-class: 1.9 
      +/- 0.7). Echocardiography was performed with assessment of global longitudinal 
      LV strain (epsilon) and LA epsilon and strain-rate parameters (systolic, early 
      diastolic, and late diastolic during atrial contraction). Each patient received 
      delayed-enhancement magnetic resonance imaging (DE-MRI) to check for myocardial 
      fibrosis. We divided the patients into two groups. Patients of group 1 had no 
      fibrosis, group 2 demonstrated moderate or severe fibrosis in > or = 2 segments 
      using a 17 segment-model of the LV. RESULTS: Moderate and severe fibrosis was 
      observed in 20 patients (group 2: 66.7%). Global longitudinal LV epsilon (-13.0 
      +/- 2.4 vs -20.6 +/- 3.2%, P < 0.001) and peak LA epsilon (-0.2 +/- 3.9 vs 17.9 
      +/- 6.7%, P < 0.001) were reduced in group 2 in comparison with patients without 
      myocardial fibrosis. In all patients peak LA epsilon correlated with global 
      longitudinal LV epsilon (r = -0.78, P < 0.001). Patients with considerable 
      myocardial fibrosis (group 2) had a higher indexed left atrial volume (35.7 +/- 
      12.8 ml/m2 vs 24.1 +/- 8.6 ml/m2, P = 0.016). New York Heart Association class 
      (NYHA) was higher in patients with severe myocardial fibrosis (2.2 +/- 0.7 vs 1.3 
      +/- 0.5) and correlated with peak LA (r = -0.5, P = 0.008) and global LV epsilon 
      (r = 0.5, P = 0.005). CONCLUSIONS: Occurrence of myocardial fibrosis in 
      hypertrophic cardiomyopathy is associated with left atrial and ventricular 
      dysfunction as well as with the severity of heart failure symptoms.
FAU - Prinz, Christian
AU  - Prinz C
AD  - Dept. of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr 
      University Bochum, Bad Oeynhausen, Germany. Cchrprinz@aol.com
FAU - Van Buuren, Frank
AU  - Van Buuren F
FAU - Bogunovic, Nicola
AU  - Bogunovic N
FAU - Bitter, Thomas
AU  - Bitter T
FAU - Faber, Lothar
AU  - Faber L
FAU - Horstkotte, Dieter
AU  - Horstkotte D
LA  - eng
PT  - Journal Article
PL  - England
TA  - Acta Cardiol
JT  - Acta cardiologica
JID - 0370570
RN  - 0 (Contrast Media)
SB  - IM
MH  - Adult
MH  - Algorithms
MH  - *Atrial Function, Left
MH  - Cardiomyopathy, Hypertrophic/diagnostic imaging/*pathology/*physiopathology
MH  - Contrast Media
MH  - *Echocardiography
MH  - Electrocardiography
MH  - Female
MH  - Fibrosis
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Ventricular Dysfunction, Left/diagnostic imaging/*pathology/*physiopathology
EDAT- 2012/05/31 06:00
MHDA- 2012/07/24 06:00
CRDT- 2012/05/31 06:00
PHST- 2012/05/31 06:00 [entrez]
PHST- 2012/05/31 06:00 [pubmed]
PHST- 2012/07/24 06:00 [medline]
AID - 10.1080/ac.67.2.2154209 [doi]
PST - ppublish
SO  - Acta Cardiol. 2012 Apr;67(2):187-93. doi: 10.1080/ac.67.2.2154209.