PMID- 22642961
OWN - NLM
STAT- MEDLINE
DCOM- 20130121
LR  - 20221207
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 39
IP  - 1
DP  - 2012 Oct 1
TI  - The role of brain-derived neurotrophic factor (BDNF) gene variants in 
      antipsychotic response and antipsychotic-induced weight gain.
PG  - 96-101
LID - 10.1016/j.pnpbp.2012.05.014 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) has extensive effects on the 
      nervous system including cell survival, differentiation, neuronal growth and 
      maintenance, as well as cell death. Moreover, it promotes synaptic plasticity and 
      interacts with dopaminergic and serotonergic neurons, suggesting an important 
      role on the alteration of brain function with antipsychotic medications and 
      induced weight gain in schizophrenia patients. The differential effects of BDNF 
      gene variants could lead to changes in brain circuitry that would in turn cause 
      variable response to antipsychotic medication. Therefore, we hypothesized that 
      genetic variation in this candidate gene helps in explaining the inter-individual 
      variation observed in antipsychotic drug treatment with respect to response and 
      induced weight gain. METHOD: We examined four single-nucleotide polymorphisms 
      across the BDNF gene, including Val66Met (rs6265). Prospective BPRS change scores 
      and weight change after six weeks were obtained from a total of 257 schizophrenia 
      patients of European ancestry. RESULTS: The markers rs11030104 and Val66Met were 
      associated with antipsychotic response (P=0.04; 0.007, respectively). On the 
      other hand, marker rs1519480 was associated with weight gain (P=0.04). Moreover, 
      a two-marker haplotype across rs6265 and rs1519480 was associated with weight 
      change (P=0.001). Results with Val66Met in response, and results with 
      rs6265-rs1519480 haplotypes remained significant at the modified Bonferroni 
      corrected alpha of 0.017. CONCLUSION: BDNF genetic variants might play an 
      important role in predicting antipsychotic response and antipsychotic-induced 
      weight gain. However, replication in larger and independent samples is required.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Zai, Gwyneth C M
AU  - Zai GC
AD  - Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, ON M5T 
      1R8, Canada. gwyneth_zai@camh.net
FAU - Zai, Clement C H
AU  - Zai CC
FAU - Chowdhury, Nabilah I
AU  - Chowdhury NI
FAU - Tiwari, Arun K
AU  - Tiwari AK
FAU - Souza, Renan P
AU  - Souza RP
FAU - Lieberman, Jeffrey A
AU  - Lieberman JA
FAU - Meltzer, Herbert Y
AU  - Meltzer HY
FAU - Potkin, Steven G
AU  - Potkin SG
FAU - Muller, Daniel J
AU  - Muller DJ
FAU - Kennedy, James L
AU  - Kennedy JL
LA  - eng
GR  - MOP 115097/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20120527
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antipsychotic Agents/*adverse effects/therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Clinical Trials as Topic
MH  - Female
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics/physiology
MH  - Psychiatric Status Rating Scales/statistics & numerical data
MH  - Schizophrenia/drug therapy/*genetics
MH  - Treatment Outcome
MH  - Weight Gain/drug effects/*genetics/physiology
MH  - White People/genetics
EDAT- 2012/05/31 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/05/31 06:00
PHST- 2012/02/29 00:00 [received]
PHST- 2012/05/17 00:00 [revised]
PHST- 2012/05/19 00:00 [accepted]
PHST- 2012/05/31 06:00 [entrez]
PHST- 2012/05/31 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - S0278-5846(12)00116-9 [pii]
AID - 10.1016/j.pnpbp.2012.05.014 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39(1):96-101. doi: 
      10.1016/j.pnpbp.2012.05.014. Epub 2012 May 27.