PMID- 22645946
OWN - NLM
STAT- MEDLINE
DCOM- 20120731
LR  - 20181201
IS  - 0869-8139 (Print)
IS  - 0869-8139 (Linking)
VI  - 98
IP  - 3
DP  - 2012 Mar
TI  - [Expression of the genes Egf and Egfr in renal tissue of the hypertensive rats of 
      the ISIAH strain].
PG  - 373-80
AB  - Activation of the epidermal growth factor receptors (EGFR) plays an important 
      role in the regulation of the kidney blood circulation and ion transport. The 
      mRNA content of the epidermal growth factor (Egf) and its receptor (Egfr) genes 
      were studied in the cortical and medullar parts of the kidney of rats with stress 
      sensitive arterial hypertension (ISIAH strain) and normotensive WAG rats. There 
      were no differences in the Egf expression between the rat strains at rest and 
      under emotional stress in both the cortical and medullary kidney zones. As for 
      Egfr transcription, it was significantly higher in the cortical and medullary 
      parts of the ISIAH kidneys at rest as compared to the control WAG. Emotional 
      stress induced no significant changes in the Egfr transcription in the cortical 
      kidney parts of both rat strains. But prominent enhancement of Egfr transcription 
      after emotional stress was observed in the kidney medulla of the WAG rats: it 
      became the same as in the ISIAH rats at rest. It was suggested that the stress 
      hormones might be involved in the regulation of Egfr transcription, and this 
      connection between stress and Egfr gene activity might play a significant role in 
      the kidney involvement in pathogenesis of stress sensitive arterial hypertension.
FAU - Pyl'nik, T O
AU  - Pyl'nik TO
FAU - Redina, O E
AU  - Redina OE
FAU - Smolehskaia, S E
AU  - Smolehskaia SE
FAU - Ivanova, L N
AU  - Ivanova LN
FAU - Markel', A L
AU  - Markel' AL
LA  - rus
PT  - Journal Article
PL  - Russia (Federation)
TA  - Ross Fiziol Zh Im I M Sechenova
JT  - Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova
JID - 9715665
RN  - 0 (RNA, Messenger)
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Adrenal Cortex/*metabolism
MH  - Adrenal Medulla/*metabolism
MH  - Animals
MH  - Blood Pressure
MH  - Epidermal Growth Factor/genetics/*metabolism
MH  - ErbB Receptors/genetics/*metabolism
MH  - Gene Expression Regulation
MH  - Hypertension/metabolism/pathology
MH  - Kidney/*metabolism
MH  - Male
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - *Stress, Psychological
EDAT- 2012/06/01 06:00
MHDA- 2012/08/01 06:00
CRDT- 2012/06/01 06:00
PHST- 2012/06/01 06:00 [entrez]
PHST- 2012/06/01 06:00 [pubmed]
PHST- 2012/08/01 06:00 [medline]
PST - ppublish
SO  - Ross Fiziol Zh Im I M Sechenova. 2012 Mar;98(3):373-80.