PMID- 22646693
OWN - NLM
STAT- MEDLINE
DCOM- 20130708
LR  - 20131121
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 5
IP  - 1
DP  - 2013 Mar
TI  - Dietary supplementation with Ipomoea aquatica (whole leaf powder) attenuates 
      maternal and fetal oxidative stress in streptozotocin-diabetic rats.
PG  - 25-33
LID - 10.1111/j.1753-0407.2012.00210.x [doi]
AB  - BACKGROUND: The rate of congenital anomalies, as well as morbidity and mortality 
      of both the mother and fetus, is increased in diabetic pregnancy. Oxidative 
      stress (OS) has been implicated in these effects because of the beneficial 
      effects of several antioxidants in diabetic embryopathy. In the present study, we 
      assessed attenuation of maternal and fetal OS and diabetic embryopathy by Ipomoea 
      aquatica Forsk. (Convolvulaceae). METHODS: Pregnant rats were divided into four 
      groups: Group I, untreated non-diabetic control; Group II, rats fed a 2%I. 
      aquatica (IA)-supplemented diet; Group III, streptozotocin (STZ)-diabetic rats 
      fed a normal diet; Group IV, STZ-diabetic rats fed an IA-supplemented diet. Rats 
      were rendered diabetic with a single injection of STZ (40 mg/kg) on gestational 
      day (GD) 4. Dams were killed on GD20 and markers of OS were determined in the 
      maternal liver and fetal brain and liver. RESULTS: Embryopathy increased 
      significantly in STZ-diabetic rats (by 40% versus control), but IA 
      supplementation provided significant protection (36% reduction in embryopathy in 
      the IA group versus the STZ-diabetic group). Interestingly, IA supplementation 
      significantly offset diabetes-associated OS in the maternal liver, as evidenced 
      by reductions in malondialdehyde (MDA; 25% reduction versus STZ-diabetes) and 
      reactive oxygen species (ROS; 72% reduction) and increases in glutathione (53% 
      reduction) and total thiols (45% reduction). In addition, IA supplementation 
      offered significant protection against diabetes-induced OS in the fetal brain and 
      liver, as evidenced by increased levels of antioxidant molecules and enzymes and 
      reductions in ROS and MDA compared with fetuses from STZ-diabetic rats. 
      CONCLUSIONS: The data suggest that IA supplementation during pregnancy provides 
      considerable protection against diabetes-induced OS in the mother and fetus. 
      Thus, I. aquatica may be an effective therapeutic supplement.
CI  - (c) 2012 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley 
      Publishing Asia Pty Ltd.
FAU - Shivananjappa, Mahesh M
AU  - Shivananjappa MM
AD  - Department of Biochemistry and Nutrition, Central Food Technological Research 
      Institute, Council of Scientific and Industrial Research, Mysore, Karnataka, 
      India.
FAU - Muralidhara
AU  - Muralidhara
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
RN  - 0 (Powders)
RN  - 0 (Reactive Oxygen Species)
RN  - 5W494URQ81 (Streptozocin)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Experimental/*metabolism
MH  - *Dietary Supplements
MH  - Female
MH  - Fetus/*metabolism
MH  - *Ipomoea
MH  - Lipid Peroxidation
MH  - *Oxidative Stress
MH  - *Plant Leaves
MH  - Powders
MH  - Pregnancy
MH  - Rats
MH  - Rats, Wistar
MH  - Reactive Oxygen Species/metabolism
MH  - Streptozocin
EDAT- 2012/06/01 06:00
MHDA- 2013/07/09 06:00
CRDT- 2012/06/01 06:00
PHST- 2012/06/01 06:00 [entrez]
PHST- 2012/06/01 06:00 [pubmed]
PHST- 2013/07/09 06:00 [medline]
AID - 10.1111/j.1753-0407.2012.00210.x [doi]
PST - ppublish
SO  - J Diabetes. 2013 Mar;5(1):25-33. doi: 10.1111/j.1753-0407.2012.00210.x.