PMID- 22647522
OWN - NLM
STAT- MEDLINE
DCOM- 20121204
LR  - 20160801
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 46
IP  - 8
DP  - 2012 Aug
TI  - Elevated interleukin-18 serum levels in chronic schizophrenia: Association with 
      psychopathology.
PG  - 1093-8
LID - 10.1016/j.jpsychires.2012.04.026 [doi]
AB  - BACKGROUND: Schizophrenia is associated with various abnormalities in the immune 
      system including elevated levels of Interleukin-18 (IL-18), a potent inflammatory 
      cytokine in T-helper 1 (Th1) responses. The aim of this study was to assess the 
      clinical significance of serum IL-18 levels in various stages of schizophrenia. 
      METHODS: We measured serum IL-18 levels using a sandwich enzyme-linked 
      immunosorbent assay (ELISA) from 78 never-medicated first-episode schizophrenia, 
      79 medicated chronic schizophrenia and 78 healthy control subjects. The symptoms 
      of schizophrenia were assessed by the Positive and Negative Syndrome Scale 
      (PANSS). RESULTS: The chronic patients had significantly greater serum IL-18 
      levels than both first-episode patients and controls. Serum IL-18 was also 
      positively correlated with the PANSS general psychopathology subscore in chronic 
      schizophrenic patients. CONCLUSIONS: Our results showed elevated IL-18 pathway 
      activity may be involved in the psychopathology of schizophrenia.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Xiu, Mei Hong
AU  - Xiu MH
AD  - Psychiatry Research Center, Beijing HuiLongGuan Hospital, Peking University, 
      Beijing, China.
FAU - Chen, Da Chun
AU  - Chen DC
FAU - Wang, Dong
AU  - Wang D
FAU - Zhang, Kui
AU  - Zhang K
FAU - Dong, AiLing
AU  - Dong A
FAU - Tang, Wei
AU  - Tang W
FAU - Zhang, Feixue
AU  - Zhang F
FAU - Liu, Lian Jing
AU  - Liu LJ
FAU - Liu, Jia Hong
AU  - Liu JH
FAU - Liu, Hai Bo
AU  - Liu HB
FAU - Yang, Fu De
AU  - Yang FD
FAU - Kosten, Thomas R
AU  - Kosten TR
FAU - Zhang, Xiang Yang
AU  - Zhang XY
LA  - eng
GR  - K05-DA0454/DA/NIDA NIH HHS/United States
GR  - P50-DA18827/DA/NIDA NIH HHS/United States
GR  - U01 MH79639/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120528
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Antipsychotic Agents/therapeutic use
MH  - Chronic Disease
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Interleukin-18/*blood
MH  - Male
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/*blood/drug therapy
MH  - *Schizophrenic Psychology
MH  - Statistics as Topic
MH  - Young Adult
EDAT- 2012/06/01 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/06/01 06:00
PHST- 2012/02/22 00:00 [received]
PHST- 2012/04/13 00:00 [revised]
PHST- 2012/04/26 00:00 [accepted]
PHST- 2012/06/01 06:00 [entrez]
PHST- 2012/06/01 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - S0022-3956(12)00140-9 [pii]
AID - 10.1016/j.jpsychires.2012.04.026 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2012 Aug;46(8):1093-8. doi: 10.1016/j.jpsychires.2012.04.026. 
      Epub 2012 May 28.