PMID- 22648004
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20221207
IS  - 1476-5470 (Electronic)
IS  - 1466-4879 (Linking)
VI  - 13
IP  - 6
DP  - 2012 Sep
TI  - CD14 polymorphisms correlate with an augmented risk for celiac disease in Italian 
      patients.
PG  - 489-95
LID - 10.1038/gene.2012.23 [doi]
AB  - Celiac disease (CD) is a T-cell-mediated chronic inflammatory disease 
      characterized by autoimmune, immunological and environmental components, where 
      genetic factors in addition to the main known risk factors (gliadin and human 
      leukocyte antigen (HLA)-DQ haplotypes) are supposed to be involved. CD14 is a 
      multifunctional receptor involved in the bacterial lipopolysaccharides-dependent 
      signal transduction. The CD14 gene maps on the long arm of chromosome 5 
      (5q22-q32), a 'hotbed' region for CD; promoter polymorphisms are known to 
      influence its expression. In this study we analyzed three CD14 promoter 
      polymorphisms (c.-1359G>T, c.-1145A>G and c.-159C>T, ) in 938 CD Italian patients 
      and 533 healthy controls, with known HLA-DQ haplotypes, with the aim of 
      evaluating their possible association with the disease. The c.-1145A>G G and 
      c.-159C>T T alleles (as well as the combination of the two alleles in the GT 
      haplotype), were identified as susceptibility factors for CD development, being 
      significantly more frequent in CD patients than in healthy controls. This 
      association was also confirmed when the analysis was restricted to only those 
      subjects characterized by HLA-DQ risk haplotypes. Our results indicate the 
      involvement of CD14 gene polymorphisms in the susceptibility to CD.
FAU - Catamo, E
AU  - Catamo E
AD  - Institute for Maternal and Child Health - IRCCS Burlo Garofolo, Trieste, 
      University of Trieste, Trieste, Italy.
FAU - Segat, L
AU  - Segat L
FAU - Lenarduzzi, S
AU  - Lenarduzzi S
FAU - Petix, V
AU  - Petix V
FAU - Morgutti, M
AU  - Morgutti M
FAU - Crovella, S
AU  - Crovella S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120531
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (HLA Antigens)
RN  - 0 (Lipopolysaccharide Receptors)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Celiac Disease/*genetics/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/genetics
MH  - Haplotypes
MH  - Humans
MH  - Infant
MH  - Italy
MH  - Linkage Disequilibrium
MH  - Lipopolysaccharide Receptors/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - White People/genetics
MH  - Young Adult
EDAT- 2012/06/01 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/06/01 06:00
PHST- 2012/06/01 06:00 [entrez]
PHST- 2012/06/01 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
AID - gene201223 [pii]
AID - 10.1038/gene.2012.23 [doi]
PST - ppublish
SO  - Genes Immun. 2012 Sep;13(6):489-95. doi: 10.1038/gene.2012.23. Epub 2012 May 31.