PMID- 22648490 OWN - NLM STAT- MEDLINE DCOM- 20121022 LR - 20120531 IS - 1098-9048 (Electronic) IS - 1069-3424 (Linking) VI - 33 IP - 2 DP - 2012 Apr TI - Interventional approaches in VTE treatment (vena cava filters, catheter-guided thrombolysis, thrombosuction). PG - 176-85 LID - 10.1055/s-0032-1311796 [doi] AB - Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most common cardiovascular pathology after coronary disease and cerebrovascular diseases and is responsible for significant morbidity and mortality in the general population. Full-dose anticoagulation is the standard therapy for VTE, both the acute phase and the prolonged treatment. The latest guidelines of the American College of Chest Physicians recommend treatment with a full-dose of unfractionated heparin (UFH), low-molecular-weight-heparin (LMWH), fondaparinux, vitamin K antagonist (VKA), or systemically administered thrombolytics for most of the patients with objectively confirmed VTE. Catheter-guided thrombolysis and thrombosuction are interventional approaches that should be used only in selected populations; interruption of the inferior vena cava (IVC) with a filter can be performed to prevent life-threatening PE in patients with VTE and contraindications to anticoagulant treatment, bleeding complications during antithrombotic treatment, or VTE recurrences, despite optimal anticoagulation. This review summarizes the currently available literature regarding interventional approaches in VTE treatment (vena cava filters, catheter-guided thrombolysis, thrombosuction), discusses their efficacy and safety, and reviews the appropriate indications for their use in daily clinical practice. CI - Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. FAU - Imberti, Davide AU - Imberti D AD - Department of Internal Medicine, Piacenza Hospital, Via Taverna 49, Piacenza, Italy. d.imberti@ausl.pc.it FAU - Maraldi, Cinzia AU - Maraldi C FAU - Gallerani, Massimo AU - Gallerani M LA - eng PT - Journal Article PT - Review DEP - 20120530 PL - United States TA - Semin Respir Crit Care Med JT - Seminars in respiratory and critical care medicine JID - 9431858 RN - 0 (Anticoagulants) SB - IM MH - Anticoagulants/administration & dosage/therapeutic use MH - Catheterization/adverse effects/methods MH - Humans MH - Mechanical Thrombolysis/adverse effects/methods MH - *Practice Guidelines as Topic MH - Pulmonary Embolism/epidemiology/pathology/*therapy MH - Thrombolytic Therapy/adverse effects/methods MH - Vena Cava Filters/adverse effects MH - Venous Thrombosis/epidemiology/pathology/*therapy EDAT- 2012/06/01 06:00 MHDA- 2012/10/23 06:00 CRDT- 2012/06/01 06:00 PHST- 2012/06/01 06:00 [entrez] PHST- 2012/06/01 06:00 [pubmed] PHST- 2012/10/23 06:00 [medline] AID - 10.1055/s-0032-1311796 [doi] PST - ppublish SO - Semin Respir Crit Care Med. 2012 Apr;33(2):176-85. doi: 10.1055/s-0032-1311796. Epub 2012 May 30.