PMID- 22649228
OWN - NLM
STAT- MEDLINE
DCOM- 20120806
LR  - 20211021
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 32
IP  - 22
DP  - 2012 May 30
TI  - Altered distribution of juxtaparanodal kv1.2 subunits mediates peripheral nerve 
      hyperexcitability in type 2 diabetes mellitus.
PG  - 7493-8
LID - 10.1523/JNEUROSCI.0719-12.2012 [doi]
AB  - Peripheral nerve hyperexcitability (PNH) is one of the distal peripheral 
      neuropathy phenotypes often present in patients affected by type 2 diabetes 
      mellitus (T2DM). Through in vivo and ex vivo electrophysiological recordings in 
      db/db mice, a model of T2DM, we observed that, in addition to reduced nerve 
      conduction velocity, db/db mice also develop PNH. By using pharmacological 
      inhibitors, we demonstrated that the PNH is mediated by the decreased activity of 
      K(v)1-channels. In agreement with these data, we observed that the diabetic 
      condition led to a reduced presence of the K(v)1.2-subunits in juxtaparanodal 
      regions of peripheral nerves in db/db mice and in nerve biopsies from T2DM 
      patients. Together, these observations indicate that the T2DM condition leads to 
      potassium channel-mediated PNH, thus identifying them as a potential drug target 
      to treat some of the DPN related symptoms.
FAU - Zenker, Jennifer
AU  - Zenker J
AD  - Department of Medical Genetics and Graduate Program in Neurosciences, University 
      of Lausanne, CH-1005 Lausanne, Switzerland.
FAU - Poirot, Olivier
AU  - Poirot O
FAU - de Preux Charles, Anne-Sophie
AU  - de Preux Charles AS
FAU - Arnaud, Estelle
AU  - Arnaud E
FAU - Medard, Jean-Jacques
AU  - Medard JJ
FAU - Lacroix, Catherine
AU  - Lacroix C
FAU - Kuntzer, Thierry
AU  - Kuntzer T
FAU - Chrast, Roman
AU  - Chrast R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Blood Glucose)
RN  - 0 (Kv1.2 Potassium Channel)
RN  - 0 (Potassium Channel Blockers)
RN  - 0 (Protein Subunits)
RN  - 0 (Receptors, Leptin)
RN  - 0 (Sodium Channel Blockers)
RN  - 0 (Sodium Channels)
RN  - 4368-28-9 (Tetrodotoxin)
SB  - IM
MH  - Action Potentials/drug effects/genetics
MH  - Age Factors
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Body Weight/drug effects/genetics
MH  - Diabetes Mellitus, Type 2/complications/pathology
MH  - Disease Models, Animal
MH  - Electric Stimulation
MH  - Humans
MH  - Kv1.2 Potassium Channel/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Mutant Strains
MH  - Mutation/genetics
MH  - Neural Conduction/physiology
MH  - Peripheral Nerves/*metabolism/*physiopathology
MH  - Peripheral Nervous System Diseases/etiology/*pathology
MH  - Potassium Channel Blockers/pharmacology
MH  - Protein Subunits/metabolism
MH  - Ranvier's Nodes/*metabolism
MH  - Receptors, Leptin/genetics
MH  - Sodium Channel Blockers/pharmacology
MH  - Sodium Channels/metabolism
MH  - Tetrodotoxin/pharmacology
PMC - PMC6703576
EDAT- 2012/06/01 06:00
MHDA- 2012/08/07 06:00
PMCR- 2012/11/30
CRDT- 2012/06/01 06:00
PHST- 2012/06/01 06:00 [entrez]
PHST- 2012/06/01 06:00 [pubmed]
PHST- 2012/08/07 06:00 [medline]
PHST- 2012/11/30 00:00 [pmc-release]
AID - 32/22/7493 [pii]
AID - 3777505 [pii]
AID - 10.1523/JNEUROSCI.0719-12.2012 [doi]
PST - ppublish
SO  - J Neurosci. 2012 May 30;32(22):7493-8. doi: 10.1523/JNEUROSCI.0719-12.2012.