PMID- 22650037
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20211203
IS  - 1672-173X (Print)
IS  - 1672-173X (Linking)
VI  - 43
IP  - 2
DP  - 2012 Mar
TI  - [From research of BDNF in traumatic brain and spinal cord injury to translational 
      medicine].
PG  - 226-30
AB  - Brain and spinal cord injury (BSI), a common neurological disease, is increasing. 
      The functional recovery of BSI is far from satisfactory despite great improvement 
      in clinical treatment of BSI. Research into injury of neurons and neurite as well 
      as the microenvironment that regulate BSI conditions should be able to enable us 
      to find a pivotal position among the complex molecular system for effective 
      clinic practice. Further effort needs to pay attention to translational research. 
      In this paper, we propose a crucial molecule, known as brain derived neurotrophic 
      factor (BDNF), for translational research in relation to BSI because of its 
      significant role in BSI and its changes with various interventions such as 
      acupuncture, hormone, herb and cell agents. Moreover, the establishment of BDNF 
      transgenic release would provide a practical approach for treating BSI with BDNF. 
      It is important that research questions derive from bedsides (what do doctors and 
      patients need?). Answers identified by laboratory research should be put into 
      practice (back to bedsides). This consists of B-to-B double circles. As a key 
      concept of translational medicine, it will guide our direction towards optimal 
      development of medical research and medical practice.
FAU - Wang, Ting-Hua
AU  - Wang TH
AD  - State Key Laboratory of Biotherapy, Translational Neuroscience Center, West China 
      Hospital, Sichuan University, Chengdu 610041, China.
FAU - Liu, Jin
AU  - Liu J
LA  - chi
PT  - Journal Article
PL  - China
TA  - Sichuan Da Xue Xue Bao Yi Xue Ban
JT  - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical 
      science edition
JID - 101162609
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Brain Injuries/*metabolism/therapy
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Spinal Cord Injuries/*metabolism/therapy
MH  - *Translational Research, Biomedical
EDAT- 2012/06/02 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/06/02 06:00
PHST- 2012/06/02 06:00 [entrez]
PHST- 2012/06/02 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
PST - ppublish
SO  - Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 Mar;43(2):226-30.